Comparison of the Alveolar Ridge Dimensions Following Simple Extraction of Maxillary and Mandibular Molars With and Without the Use of Local Simvastatin in Post-Extraction Socket: A Randomized Clinical Study.

Comparative Evaluation of the Alveolar Ridge Preservation Following Intra Alveolar Extraction of Maxillary and Mandibular Molars With and Without the Use of Local Simvastatin: A Randomized Clinical Study. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/03/063965

Enrollment

Registered

2024-03-11

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K029- Dental caries, unspecified

Interventions

Intervention1: 10mg Simvastatin: Topical Simvastatin is packed in the socket along with absorbable gelatin sponge for 3 months Control Intervention1: Absorbable gelatin sponge: Only absorbable gelatin

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients indicated for maxillary and mandibular molar intra alveolar extraction under local anaesthesia. 2. Tooth with adjacent teeth present and intact. 3. Tooth indicated for extraction without any radiographically evident periapical lesion. 4. Patients willing to be a part of the study.

Exclusion criteria

Exclusion criteria: 1. Teeth which require transalveolar method of extraction under local anaesthesia. 2. Patients indicated for maxillary and mandibular third molar extractions. 3. Patients with uncontrolled periodontal diseases. 4. Patients with known allergy to statins. 5. Patients with systemic comorbidities that are contraindications for extraction and affect bone metabolism and healing. 6. Patients on steroid therapy. 7. Patients undergoing radiotherapy. 8. Smokers and Alcoholics. 9. Pregnancy based on history.

Design outcomes

Primary

Measure	Time frame
To evaluate and compare efficacy of locally applied simvastatin in alveolar ridge preservation in post extraction sockets of maxillary and mandibular molars.Timepoint: Immediate post extraction, at 8 weeks, at 12 weeks	—

Secondary

Measure	Time frame
To evaluate and compare bone density following intra alveolar extraction of maxillary and mandibular molars with and without the use of local simvastatin.Timepoint: Immediate post extraction, at 8 weeks, at 12 weeks	—

Countries

India

Contacts

Public ContactDR CHARLOTTE SALDANHA

MGM DENTAL COLLEGE AND HOSPITAL, KAMOTHE

drushaasnani@gmail.com9820897181

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026