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Regeneration of damaged enamel by application of a peptide

Clinical evaluation of biomimetic self assembling peptide in remineralization of early buccal carious lesion - A Randomized Control Trial. - NIL

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/03/063933
Enrollment
40
Registered
2024-03-11
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K026- Dental caries on smooth surface

Interventions

Intervention1: P11-4 PEPTIDE AND NANOHYROXYAPATITE: 0.5mg of the p11-4 peptide is mixed with 0.05ml of sterile water and 10% aqueous slurry of nanohydroxyapatite, applied topically and left undisturbe

Sponsors

Harini J Raj
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Teeth selection: Surfaces included: buccal Subjects with =1 visible and accessible early caries lesion present, which did not require operative intervention. Patient selection: Age group:18–60years Had to provide written informed consent prior to any study procedures and needed to be able and willing to observe good oral hygiene throughout the study duration

Exclusion criteria

Exclusion criteria: Subjects receiving the following medications were excluded from the study: tetracyclines, any other medication known to stain teeth. Subjects who are pregnant and breast feeding should be excluded from the study Subjects who has evidence of reduced salivary flow or excessive tooth wear. Subjects >1 carious lesion on the selected teeth

Design outcomes

Primary

MeasureTime frame
remineralization of early buccal carious lesionTimepoint: 1,3 and 6 months

Secondary

MeasureTime frame
improved oral hygiene improvement in aestheticsTimepoint: 1,3 and 6 months

Countries

India

Contacts

Public ContactHarini J Raj

VS Dental college and hospital

anithamanasi18@gmail.com9845919324

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026