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A clinical study to compare the effectiveness of reducing post operative sore throat in tonsillectomy following dexmedetomidine intraoral spray versus ketamine intraoral spray

A comparative study to evaluate the attenuation of post operative sore throat in tonsillectomy following dexmedetomidine intraoral spray versus ketamine intraoral spray: A clinical study - NIL

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/03/063919
Enrollment
60
Registered
2024-03-11
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J350- Chronic tonsillitis and adenoiditis

Interventions

Intervention1: Dexmedetomidine intraoral spray: Dexmedetomidine intraoral spray(2mcg/kg) is given 2 minutes before intubation under direct laryngoscopy. Control Intervention1: Ketamine intraoral spray

Sponsors

Dr Ranadhee Paul
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Only ASA I and II without any anticipated difficult airway (MPS -I & II) will be included . 2.Patients between age 12-30 years 3.Patients of both sexes 4.Patients scheduled for elective tonsillectomy under general anaesthesia

Exclusion criteria

Exclusion criteria: 1.Refusal to valid informed consent. 2.History of allergy to the study drugs. 3. Patients with Cardiovascular, respiratory, renal , hepatic or neuromuscular diseases. 4. Patients with a history of preoperative sore throat, asthma, respiratory tract infection,consumption of analgesic in preoperative period, operating time more than 90 minutes, and requirement of more than one attempt for passage of endotracheal tube.

Design outcomes

Primary

MeasureTime frame
To determine whether Dexmedetomidine or Ketamine intraoral spray is more effective in attenuating the post-operative sore throat in tonsillectomy.Timepoint: Comparing the time required for attenuation of sore throat in the two groups of participants at 0 hour, 2 hours, 6 hours 12 hours 18 hours and 24 hours post operatively.

Secondary

MeasureTime frame
To evaluate any adverse effects of the drugs used i.e. Dexmedetomidine & Ketamine intraoral spray.Timepoint: To evaluate adverse effects of the drugs at 0 hour, 2 hours, 6 hours, 12 hours, 18 hours, 24 hours post operatively

Countries

India

Contacts

Public ContactDr Ranadhee Paul

Silchar Medical College And Hospital

binoy.bihari@gmail.com7002334288

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026