Health Condition 1: F333- Major depressive disorder, recurrent, severe with psychotic symptoms Health Condition 2: F339- Major depressive disorder, recurrent, unspecified Health Condition 3: F315- Bipolar disorder, current episodedepressed, severe, with psychotic features
Conditions
Interventions
Intervention1: Etomidate: Patients will receive intravenous etomidate(aqueous) 0.3 mg/Kg for General Anesthesia.
Total procedure duration 30 mins.
Control Intervention1: Thiopentone: Patients will r
Sponsors
Institute of Neurosciences Kolkata
Eligibility
Inclusion criteria
Inclusion criteria: i) Patients between 18 to 65 years of age posted for modified electroconvulsive therapy. ii) ASA1,2. iii) Either sex
Exclusion criteria
Exclusion criteria: i)Patients with a history of adverse reactions to either thiopentone or etomidate, ii) Patients with a history of cardiovascular, respiratory, neurological disease or electrolyte imbalance iii)Severe arterial hypertension iv)ASA 3,4.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Duration of seizure activityTimepoint: Onset of visible contractions to end of visible contractions | — |
Secondary
| Measure | Time frame |
|---|---|
| Cardiovascular and respiratory parameters (heart rate, blood pressure, oxygen saturation) Timepoint: Basal, After induction and 1 min, 2 min, 3 min, 5 min, 10 min, 20 min, and 30 min following MECT;Time to recovery of consciousness and orientationTimepoint: N/A;Adverse effects such as nausea, vomiting, headache, and myoclonusTimepoint: Anytime in the first 12 hours after ECT. | — |
Countries
India
Contacts
Public ContactBibhukalyani Das
Institute of Neurosciences Kolkata
Outcome results
None listed