Evaluation of Manasa Bhava and Rasa Dhatu Dushthi in the etiopathogenesis of Akalaja Palitya (Premature Canities) and comparative efficacy of Nimba Beeja Tail and Madhuka Tail with Brahma Rasayana in its management.

A Case Control Study to assess the role of Manasa Bhava and Rasa Dhatu Dushthi in the etiopathogenesis of Akalaja Palitya (Premature Canities) and comparative efficacy of Nimba Beeja Tail (Pratimarsha Nasya) and Madhuka Tail (Pratimarsha Nasya) with Brahma Rasayana in its management. - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/03/063872

Enrollment

Registered

2024-03-08

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L671- Variations in hair color

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: Diagnosed cases of Akalaja Palitya (Premature Canities) within the age group of 16-30 years, irrespective of their gender, religion, economic status, chronicity of the disease, and who are willing to provide informed consent for the study.

Exclusion criteria

Exclusion criteria: 1. Any kind of fungal or other infection of the scalp. 2. Any major systemic disorder. (Except DM, HTN, CAD) 3. Pregnant and lactating ladies. 4. Other skin disorders like Psoriasis, Eczema, Leucoderma etc. 5. Patient is on chemotherapy or having history of chemotherapy. 6. Know case of Pernicious anaemia

Design outcomes

Primary

Measure	Time frame
To assess the etio-pathogenic role of Manasa Bhava (Krodha, Shoka) in Akalaja Palitya (premature canities) with the help of a validated proforma.Timepoint: Assessment will be done at the time of baseline.	—

Secondary

Measure	Time frame
1. To determine the association of Rasa Dhatu Dushti lakshana as described by Acharya Charaka in Akalaja Palitya (premature canities) with the help of a self-developed validated proforma. 2. To assess the status of anxiety (HAM-A) in the study participants. 3. To assess the nutritional status (Vit. B12, Vit. D3, Sr. Calcium, Sr. Ferritin, HB) of the study participants. 4. To compare the effect of Nimba Beeja Tail (Pratimarsha Nasya) or Madhuka Tail (Pratimarsha Nasya) with Brahma Rasayana in Akalaja Patlitya patients in terms of changes in GSS score & signs & symptoms of Palitya after intervention of 90 days. 5. To assess the status of Oxidative stress index (MDA, rGSH, SOD) in the study participants (Before & after treatment).Timepoint: Assessment of GSS score, signs & symptoms of Palitya & Oxidative stress index will be done at baseline & after 3 months.	—

Measure

Time frame

1. To determine the association of Rasa Dhatu Dushti lakshana as described by Acharya Charaka in Akalaja Palitya (premature canities) with the help of a self-developed validated proforma. 2. To assess the status of anxiety (HAM-A) in the study participants. 3. To assess the nutritional status (Vit. B12, Vit. D3, Sr. Calcium, Sr. Ferritin, HB) of the study participants. 4. To compare the effect of Nimba Beeja Tail (Pratimarsha Nasya) or Madhuka Tail (Pratimarsha Nasya) with Brahma Rasayana in Akalaja Patlitya patients in terms of changes in GSS score & signs & symptoms of Palitya after intervention of 90 days. 5. To assess the status of Oxidative stress index (MDA, rGSH, SOD) in the study participants (Before & after treatment).Timepoint: Assessment of GSS score, signs & symptoms of Palitya & Oxidative stress index will be done at baseline & after 3 months.

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Countries

India

Contacts

Public ContactDr Ravikant Sharma

All India Institute of Ayurveda

drmoreanand@gmail.com9422025732

Outcome results