Health Condition 1: Z318- Encounter for other procreative management
Conditions
Interventions
Intervention1: Injection leuprolide acetate: Dose- 0.5 mg
Frequency - once a day on day 3, 5, 7, 9 and 11 of ovum pick up
Route- subcutaneous
total duration- 5 injections on day 3, 5, 7, 9 and 11 of
Sponsors
None listed
Eligibility
Inclusion criteria
Inclusion criteria: Predicted hyper-responders: fulfilling either of the three criteria, a. AFC more than 16,b. more than 13 follicles of more than 11 mm on day of GnRH agonist trigger, c.Serum estradiol levels more than 3500 pg per ml on day of trigger GnRH antagonist cycles Women aged 22 to less than 40 years Unexplained infertility Anovulatory infertility Mild to moderate male factor infertility
Exclusion criteria
Exclusion criteria: more than 25 oocytes retrieved at ovum pick up Signs of early onset OHSS Any other contraindication to fresh ET Known reasons for impaired implantation (i.e. hydrosalpinx, fibroid distorting the endometrial cavity, Asherman’s syndrome, thrombophilia or endometrial tuberculosis) Previous 2 or more failed IVF Patients who do not give written informed consent to participate BMI less than 18 or more than 30Kg per m2 Cycles with frozen spermatozoa or oocytes Oocyte donation cycles Uterine anomalies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary Outcome: Clinical pregnancy rate (Number of clinical pregnancies as determined by visualization of fetal cardiac activity on transvaginal ultrasound at 6–7weeks of gestation per embryo transfer cycles).Timepoint: at 6–7weeks of gestation per embryo transfer cycles | — |
Secondary
| Measure | Time frame |
|---|---|
| Ovarian hyperstimulation rate (OHSS rate) Hormonal dynamics (Serum LH, Progesterone (P4), Estradiol(E2) on day of ovum pick up ( day 0) , day 3, day 7 & day 14) Implantation rate : defined as number of intrauterine sac with a fetal cardiac activity determined by transvaginal ultrasound by total number of transferred embryos. Ongoing pregnancy rate defined as number of viable pregnancies beyond 12 weeks of gestation per embryo transfer Miscarriage rate defined as loss of pregnancy before 24weeks of gestation was Live birth rate : delivery of a viable fetus past 24weeks of gestation. Cancelled embryo transfer rateTimepoint: Hormonal dynamics (Serum LH, Progesterone (P4), Estradiol(E2) on day of ovum pick up ( day 0) , day 3, day 7 & day 14) Ongoing pregnancy rate defined as number of viable pregnancies beyond 12 weeks of gestation per embryo transfer Miscarriage rate defined as loss of pregnancy before 24weeks of gestation was Live birth rate : delivery of a viable fetus past 24weeks of gestation | — |
Countries
India
Contacts
Public ContactDr Archana Kumari
All India Institute of Medical Science
Outcome results
None listed