None listed
Conditions
Interventions
Intervention1: NA: NA
Control Intervention1: NA: NA
Sponsors
Indian Council of Medical Research (ICMR)
Eligibility
Inclusion criteria
Inclusion criteria: 1. Healthy asymptomatic adults aged between 50-75 years.(Absence of following symptoms: weight loss, persistent fever, anaemia, diarrhoea, rectal bleeding, constipation (recent onset within past 1 year), persistent abdominal pain). 2. Written Informed consent.
Exclusion criteria
Exclusion criteria: 1.Prior diagnosis of cancer 2.Family history of CRC: those with recognised familial genetic syndromes;those having FDRs with documented advanced adenomas. 3.Inflammatory Bowel Disease 4.Colonoscopy, gFOBT,FIT, sigmoidoscopy, barium enema done within the last 10 years 5.Recent onset of lower gastrointestinal tract symptoms (bleeding, change in bowel habit, abdominal pain, weight loss, bloating, anaemia) causing healthcare attendance in the previous 12 months. 6.Significant comorbidity (American Society of Anaesthesiologists class III or greater) 7.Previous gastrointestinal surgery 8.Participation in any other clinical trial in the previous 3 months 9.A person unlikely to be compliant or unable to give informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the prevalence of advanced colorectal neoplasia or colorectal cancer in asymptomatic healthy adults aged 50-75 years by adopting a modified risk score based screening strategy in India.Timepoint: Baseline, Follow up 1st year, Follow up 2nd year | — |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate the cost effectiveness or benefit of adopting a risk score based screening strategy.Timepoint: Baseline, Follow up 1st year, Follow up 2nd year;To evaluate the prevalence of all forms of colorectal polyps in asymptomatic healthy adults.Timepoint: Baseline, Follow up 1st year, Follow up 2nd year;To identify the contribution of each risk factor for occurrence of advanced colorectal neoplasia or colorectal cancer.Timepoint: Baseline, Follow up 1st year, Follow up 2nd year | — |
Countries
India
Contacts
Public ContactDr Vineet Ahuja
All India Institute of Medical Sciences, Delhi
Outcome results
None listed