Changes in hormonal levels of cortisol and ACTH after taking dexamethasone tablet in the night

ACTH and cortisol dynamics after overnight dexamethasone suppression - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/03/063793

Enrollment

300

Registered

2024-03-07

Start date

Unknown

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K732- Chronic active hepatitis, not elsewhere classified Health Condition 2: N184- Chronic kidney disease, stage 4 (severe) Health Condition 3: N185- Chronic kidney disease, stage 5 Health Condition 4: E243- Ectopic ACTH syndrome Health Condition 5: F339- Major depressive disorder, recurrent, unspecified Health Condition 6: E248- Other Cushings syndrome Health Condition 7: E240- Pituitary-dependent Cushings disease

Interventions

Intervention1: Blood testing for hormonal investigations: Baseline cortisol and ACTH would be tested. Patient would undergo repeat hormonal investigations next day after administration of 1mg of dexam

Eligibility

Inclusion criteria

Inclusion criteria: Newly diagnosed cushings Cushings post surgery or radiotherapy Chronic active hepatitis Depressive disorder CKD stage 4 and 5 Women on oral contraceptive pills Healthy controls

Exclusion criteria

Exclusion criteria: Exogenous cushings Drugs affecting dexamethasone metabolism Pregnancy and breastfeeding Acute illness Liver cirrhosis

Design outcomes

Primary

Measure	Time frame
To establish normative data of ACTH and cortisol after overnight dexamethasone suppression in various patient groupsTimepoint: 1 year	—

Secondary

Measure	Time frame
NILTimepoint: NIL	—

Countries

India

Contacts

Public ContactDr Saba Memon

Seth GSMC and KEMH

sabasamadmemon@gmail.com9971247224

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026