A Study Comparing two drugs(Granisetron and Ramosetron ) in preventing low blood pressure in pregnant patients undergoing caesarean section under spinal anesthesia using hyperbaric levobupivacaine.

A Prospective randomised, double blinded study to compare the effects of prophylactic intravenous administration of ramosetron and granisetron in attenuating maternal hypotension in parturients undergoing elective lower segment caesarean section under subarachnoid block using hyperbaric levobupivacaine - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/03/063785

Enrollment

120

Registered

2024-03-07

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O30-O48- Maternal care related to the fetus and amniotic cavity and possible delivery problems Health Condition 2: O00-O9A- Pregnancy, childbirth and the puerperium

Interventions

Intervention1: preemptive dose of inj. ramosetron: Inj Ramosetron 0.3 mg intravenously, 5 minutes before induction of Spinal Anaesthesia Control Intervention1: preemptive dose of inj. granisetron: Inj

Eligibility

Inclusion criteria

Inclusion criteria: Parturients belonging to ASA grade 1 and 2 more than 36 weeks gestation undergoing elective LSCS for a singleton pregnancy Parturients in the age group 18-35 years Height 150-170 cm.

Exclusion criteria

Exclusion criteria: Patient refusal Parturients with spinal deformity Parturients with medical and obstetric complications like anemia,heart disease, gestational hypertension, gestational diabetes, shock, septicemia and hypertension. Known hypersensitivity to local anesthetics and study drugs. subjects having any absolute or relative contraindications for spinal anesthesia like raised intracranial pressure, severe hypovolemia, bleeding diathesis, local infection. Parturients with BMI more than 30 kg/m2 On drugs like selective serotonin reuptake inhibitors, and migraine medications.

Design outcomes

Primary

Measure	Time frame
To compare the efficacy of prophylactic intravenous administration of Granisetron and Ramosetron in attenuating maternal hypotension in parturients undergoing lower segment cesarean section under subarachnoid block using hyperbaric levobupivacaine.Timepoint: 5 hours.	—

Secondary

Measure	Time frame
To record intraoperative hemodynamic changes with Inj.Granisetron and Inj.RamosetronTimepoint: 5 hours.	—

Countries

India

Contacts

Public ContactDr Shalini A

Mysore Medical College and Research Institute

shalinianand20@gmail.com9986061614

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026