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A comparison between two drugs in reducing the incidence of altered sensorium among patients on ventilator support

A comparison between dexmedetomidine and midazolam in reducing the incidence of delirium among mechanically ventilated ICU patients - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/03/063753
Enrollment
76
Registered
2024-03-07
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F05- Delirium due to known physiological condition Health Condition 2: F05- Delirium due to known physiological condition

Interventions

Intervention1: Dexmeditomidine and Midazolam: Group 1 will receive midazolam as IV boluses of 1 to 3 mg to achieve target RASS of -2 to +1 followed by infusion at the rate of 0.02 – 0.1 mg/kg/h. Grou

Sponsors

DEPARTMENT OF ANAESTHESIOLOGY AND CRITICAL CARE, K. S. HEGDE MEDICAL ACADEMY, DERLAKATTE
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients who are under mechanical ventilator support, need of sedation for more than 24 hours

Exclusion criteria

Exclusion criteria: Patient on neuromuscular blockers, acute neurological disorders, Atrio ventricular conduction block, lactating and pregnant women, hearing or visual impairment, mean atrial pressure less than 55mmhg

Design outcomes

Primary

MeasureTime frame
To estimate the incidence of delirium in mechanically ventilated patients receiving dexmedetomidine and midazolam.Timepoint: Twice a day at 6AM and 6PM.—

Secondary

MeasureTime frame
Need for additional sedation,Hemodynamic events requiring intervention,Length of stay in ICU.Timepoint: Assess the level of delirium using RASS & CAM ICU scores at 6AM & 6 PM—

Countries

India

Contacts

Public ContactDr. SRIPADA G MEHANDALE

K. S. HEGDE MEDICAL ACADEMY

sripadamehandale@nitte.edu.in9448384310

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026