Health Condition 1: C49- Malignant neoplasm of other connective and soft tissue
Conditions
Interventions
Intervention1: high dose ifosfamide in relapsed metastatic synovial sarcoma: injection ifosfamide 3gram per metre square given for 4 days in a 21 day cycle for 4 cycles in relapsed metastatic synovial
Sponsors
All Inida Institute of Medical sciences
Eligibility
Inclusion criteria
Inclusion criteria: Age 15 to 60 years Synovial sarcoma confirmed histologically Metastatic disease relapsed post first line of chemotherapy ECOG Performance status less than or equal to 2 Absolute Neutrophil Count more than 1000 per microliter Hemoglobin more than 8 gram per deciliter Platelet more than 100000 per microliter normal Creatinine and clearence more than 60 milliliter per minute Total bilirubin less than institutional upper limit of normal Alanine aminotransferase and aspartate aminotransferase less than 5 times upper limit of normal alkaline phosphatase less than 2.5 times upper limit of normal
Exclusion criteria
Exclusion criteria: Pregnant or breast-feeding patient Active or uncontrolled infection Locally recurrent disease which is amenable to curative surgical resection Prior therapy taken for the synovial sarcoma with high dose ifosfamide Prior grade 3 or 4 renal toxicities and any grade of encephalopathy with ifosfamide
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| OVERALL RESPONSE RATETimepoint: at 3 months | — |
Secondary
| Measure | Time frame |
|---|---|
| median progression free survival overall survival quality of lifeTimepoint: at 3 months | — |
Countries
India
Contacts
Public ContactSameer Rastogi
All inidia institute of medical sciences
Outcome results
None listed