Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: platelet rich plasma: pre and post intervention analysis after infiltration of platelet rich plasma in knee joint
Intervention2: Platelet rich plasma: Under all aseptic precautions PRP
Sponsors
JLN Medical College
Eligibility
Inclusion criteria
Inclusion criteria: Patients aged 45-65 years with either side OA knees (ASA class I and II) of either gender History of pain in last month Those with imaging findings (X-ray) of degenerative changes of the joint without significant deformity (diagnosed by KL classification ( Grade 2 and 3)
Exclusion criteria
Exclusion criteria: Patients with KL grading I ( doubtful disease) and grade 4 (Severe disease) Patient with history of diabetes mellitus On Immunosuppressive drugs Collagen vascular disorders Cancer or malignant disorders Active infection/ wound of knee Patients with autoimmune and platelet disorders Treatment with anticoagulant and antiplatelet medications within 10 days before injection Use of NSAIDs within 2 days before injection or unwilling to stop then post injection except paracetamol History of knee articular injection of corticosteroid during previous 3 months or use of systemic corticosteroids 2 weeks before PRP injection Patients with genu valgum/Varum greater than 20 degrees Human immunocompromised virus, Hepatitis B virus, Hepatitis C virus, venereal Disease Research Laboratory virus positive cases Knee surgery on affected side within last 12 months Systemic or inflammatory knee disease Presence of warm and tense joint effusion High chances of loss of follow-up History of trauma to affected knee
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pain will be assessed by WOMEC score and Visual Analogue ScoreTimepoint: Patients will be evaluated on 6 week, 3 months and 6 months after the first injection by a blinded observer for change in WOMAC score | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS scoreTimepoint: at baseline/ 6 week / 3 month and 6 months | — |
Countries
India
Contacts
Public ContactDr Veena Mathur
JLN Medical College Ajmer
Outcome results
None listed