To compare the efficacy of two different dosage of cisatracurium for rapid sequence intubation.

Comparative study of the efficacy of two different dosage of cisatracurium for endotracheal intubation during rapid sequence induction of anesthesia. A prospective randomized double blind study. - nil

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/03/063703

Enrollment

Registered

2024-03-06

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Cisatracurium of dose 0.20 mg/kg: After preoxygenation with 100% oxygen for 3 minutes, cisatracurium in 4 times ED95 dose [0.20 mg/kg] was given intravenously as a bolus dose for rapid

Eligibility

Inclusion criteria

Inclusion criteria: 1)American Society of Anesthesiology (ASA) physical status I and II. 2)Patient undergoing elective surgery lasting more than two hours under general anaesthesia. 3)Patients with no known neuromuscular diseases. 4)Patient not undergoing treatment with medications known to interfere with neuromuscular transmission. 5)Patient willing to give the written consent to participate in the study.

Exclusion criteria

Exclusion criteria: 1)Patients who refuse to give consent to the study. 2)Patients who is a known smoker, asthmatic and COPD. 3)Patients with anticipated difficulty airway. 4)Patients with known allergies to the study drug. 5) Pregnant and lactating women.

Design outcomes

Primary

Measure	Time frame
To compare the time of onset of action of two different doses of cisatracurium for rapid sequence induction of anesthesia as an indicator of efficacy. Timepoint: 1)Onset of neuromuscular block will be assessed with TOF stimulus every 12 seconds until loss of twitch response (TOF-0). 2)The blood pressure, heart rate will be recorded every minute for 10 minutes, followed by monitoring every five minutes after endotracheal intubation till the end of surgery. But statistical comparision will be done up to 30 minutes. 3)After the endotracheal tube fixation, TOF stimulation will be recorded every 5 minutes until the return of two twitches (TOF-25).	—

Measure

Time frame

To compare the time of onset of action of two different doses of cisatracurium for rapid sequence induction of anesthesia as an indicator of efficacy. Timepoint: 1)Onset of neuromuscular block will be assessed with TOF stimulus every 12 seconds until loss of twitch response (TOF-0). 2)The blood pressure, heart rate will be recorded every minute for 10 minutes, followed by monitoring every five minutes after endotracheal intubation till the end of surgery. But statistical comparision will be done up to 30 minutes. 3)After the endotracheal tube fixation, TOF stimulation will be recorded every 5 minutes until the return of two twitches (TOF-25).

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Secondary

Measure	Time frame
• To compare the duration of action of the two doses of cisatracurium administered for the rapid sequence induction. • To compare the intubating conditions during endotracheal intubation using Copenhagen consensus conference scoring system. • To compare the hemodynamic changes • To document any adverse effects. Timepoint: The blood pressure, heart rate and pulse oximetry will be recorded every minute for 10 minutes following induction of anesthesia, followed by monitoring every five minutes after endotracheal intubation till the end of surgery but documentation for statistical comparision will be done up to 30 minutes. The time from the onset of muscle relaxation (TOF-0), to the spontaneous recovery time represents the duration of action of the intubating dose of muscle relaxant.	—

Measure

Time frame

• To compare the duration of action of the two doses of cisatracurium administered for the rapid sequence induction. • To compare the intubating conditions during endotracheal intubation using Copenhagen consensus conference scoring system. • To compare the hemodynamic changes • To document any adverse effects. Timepoint: The blood pressure, heart rate and pulse oximetry will be recorded every minute for 10 minutes following induction of anesthesia, followed by monitoring every five minutes after endotracheal intubation till the end of surgery but documentation for statistical comparision will be done up to 30 minutes. The time from the onset of muscle relaxation (TOF-0), to the spontaneous recovery time represents the duration of action of the intubating dose of muscle relaxant.

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Countries

India

Contacts

Public ContactDR B Kesava Kumar

Sri Venkateswara Institute of Medical Sciences

kesavakumartamil@gmail.com08681002995

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026