Health Condition 1: J988- Other specified respiratory disorders Health Condition 2: J988- Other specified respiratory disorders
Conditions
Interventions
Intervention1: Nebulized tranexamic acid: Patients who have active hemoptysis will be administered 500 mg of TA mixed with 5ml of distilled water on arrival and three times daily in the nebulization a
Sponsors
Indian council of medical research
Eligibility
Inclusion criteria
Inclusion criteria: Patients who are above 18 years of age will be recruited in the study
Exclusion criteria
Exclusion criteria: 1.Patients already received tranexamic acid before presenting to the hospital. 2.Intubated patients on mechanical ventilation. 3.Patients with massive life-threatening hemoptysis who need to be immediately shifted for interventional procedures. 4.Patients not giving consent for participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Cessation of bleeding in patients presenting to ED with active hemoptysis at 6 hours after TA administration in both arms 2.Reduction in volume of hemoptysis at 6 h, 12 h, 24 h, 36 h and 48 h after TA administration in both armsTimepoint: 6 hours(h), 12 h, 24 h, 36 h and 48 h after TA administration in both arms | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Need for interventional procedures on ED basis and adverse effects of TA administration during ED stay for 72 hours 2.D-dimer and fibrinogen levels on arrival and at 24 and 48 hours of ED stayTimepoint: 24, 48 and 72 hours | — |
Countries
India
Contacts
Public ContactDr Prakash Ranjan Mishra
AIIMS New Delhi
Outcome results
None listed