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Effect of preoperative Olanzapine on the incidence of postoperative nausea and vomiting

Effectiveness of preoperative Olanzapine versus Placebo, as an add on drug, on the incidence of postoperative nausea and vomiting in laparoscopic gynecological surgeries: a stratified randomised control trial - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/03/063683
Enrollment
112
Registered
2024-03-06
Start date
Unknown
Completion date
Unknown
Last updated
2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N709- Salpingitis and oophoritis, unspecified Health Condition 2: N72- Inflammatory disease of cervix uteri

Interventions

Intervention1: Olanzapine: GROUP A will be given one tablet of 10mg oral olanzapine in the preoperative area, one hour before surgery and will be assessed for incidence of postoperative nausea and vo

Sponsors

Dr Prasanta Kumar Das
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Gynecological patients undergoing laparoscopic surgeries ASA 1 and 2

Exclusion criteria

Exclusion criteria: no consent, allergic to study drugs, renal and hepatic failure, on antiemetic and antipsychotic medications, prolonged qt interval, history of obstructive sleep apnea

Design outcomes

Primary

MeasureTime frame
To compare the incidence of PONV in first 24 hours after surgery between two groupsTimepoint: To compare the incidence of PONV in first 24 hours after surgery between two groups—

Secondary

MeasureTime frame
severity of nausea and vomting by 4- point severity scaleTimepoint: over 24 hours;requirement of rescue antiemetic (inj.Metoclopramide 10mg IV)Timepoint: 12 hours;Quality of recovery(QoR - 15)Timepoint: over 24 hours;Side effects of OlanzapineTimepoint: over 24 hours—

Countries

India

Contacts

Public ContactDr Nirmala Phobba

AIIMS BHUBANESWAR

anaes_prasanta@aiimsbhubaneswar.edu.in9312677007

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026