Health Condition 1: A415- Sepsis due to other Gram-negativeorganisms
Conditions
Interventions
Intervention1: Developed treatment strategy for Cr-Kp bacteremia: Personalized antimicrobial treatment strategy will be developed based on an integrated stewardship approach
Control Intervention1: Exi
Sponsors
Indian Council of Medical Research
Eligibility
Inclusion criteria
Inclusion criteria: patients diagnosed with blood stream infections due to carbapenem resistant klebsiella penumoniae anytime during their hospital stay.
Exclusion criteria
Exclusion criteria: patients received from outside hospital who had a positive culture for bacteremia after 48 hours, patients with polymicrobial bacteremia, patients with cystic fibrosis, patients who do not have a carbapenem susceptibility test or noninterpretable susceptibility test
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The integrated stewardship approach based on evidence-based recommendation will help to develop a standard treatment guideline for difficult to treat CR-Kp infections.Timepoint: After obtaining culture positive sample for Cr-Kp | — |
Secondary
| Measure | Time frame |
|---|---|
| Optimization of appropriate antibiotic regimen based on the genotype of CR-Kp will help in individualized antimicrobial therapy, providing better outcomes of the patient & prevent treatment failure or antimicrobial resistance.Timepoint: After obtaining a positive blood culture for Cr-Kp;Cost-effectiveness analysis of incorporating PCR techniques in CR-Kp will help in better management of patients in low-middle socioeconomic countries like India.Timepoint: Throughout the hospital stay of the patients based on clinical outcomes | — |
Countries
India
Contacts
Public ContactVishal Shanbhag
Kasturba Medical College, Manipal Academy of Higher Education, Manipal
Outcome results
None listed