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Use of Newer Nueromuscular reversal agent - Sugammadex vs the conventional drug Neostigmine to enhance recovery after Cardiac surgery.

ENHANCED RECOVERY AFTER CARDIAC SURGERY – USE OF SUGAMMADEX VS NEOSTIGMINE: A RANDOMIZED CONTROLLED TRIAL

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/03/063566
Enrollment
80
Registered
2024-03-04
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I080- Rheumatic disorders of both mitraland aortic valves

Interventions

Intervention1: Inj. Sugammadex 2 mg/kg Intravenously, administered once.: Neuromuscular blockage reversal after surgery using 2 mg/kg drug once, intravenously after return of TOF count 2 twitches af

Sponsors

Institutional Research Society
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: American Society of Anaesthesiologist (ASA) physical status II - III undergoing elective open heart surgeries under general anaesthesia, and requiring rocuronium-induced neuromuscular blockade will be included in the study. This includes patients undergoing - 1. Aortic valve replacement 2. Mitral valve replacement 3. Atrial septal defect closure 4. Ventricular septal defect closure

Exclusion criteria

Exclusion criteria: Aortic cross clamp time more than 100 minutes Difficulty in weaning from cardiopulmonary bypass despite adequate inotropic support Patients with preexisting DM, thyroid disorders and neuromuscular disorders Postoperative hemodynamic instability making patient not suitable for weaning from ventilator

Design outcomes

Primary

MeasureTime frame
Time to extubation in post anesthesia care unit, which is the time in minutes from procedure stop to the time of extubationTimepoint: Upto 6 hours after surgery

Secondary

MeasureTime frame
Respiratory parameters after surgery Delirium in the postoperative care unit Time to return of bowel sounds after surgery Time to first ambulation Time to discharge from ICUTimepoint: Upto 12 hours after surgery

Countries

India

Contacts

Public ContactDr Sanjeeta Umbarkar

Seth GS medical college and KEM hospital, MUMBAI

sanjeeta69@yahoo.com8879875834

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026