Health Condition 1: F20- Schizophrenia
Conditions
Interventions
Intervention1: Intermittent theta burst stimulation a type of transcranial magnetic stimulation: Intermittent theta burst stimulation (iTBS) a type of transcranial magnetic stimulation over left anter
Sponsors
Dr Pratima Murthy
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients with schizophrenia with capacity to consent. 2. Age range: 18 – 45 years 3. Patients with schizophrenia exhibiting cognitive deficits, defined as BACS scores (any domain) falling 1 or more standard deviations below the mean and standard deviation derived from a local healthy population cohort. 4. Right handed individuals assessed by Edinburgh Handedness scale. 5. Having moderate level of symptoms as measured by a score of 4 or more on Global rating on any domains in SAPS or SANS scale. 6. No contraindication for MRI and TMS (as assessed by TASS checklist) 7. No risk of harm to self or harm to others 8. No active substance use in the last 3 months (apart from nicotine).
Exclusion criteria
Exclusion criteria: 1. Features suggestive of risk of harm to self (for example: suicidal risk, catatonia, prolonged nutritional deprivation) or others (for example: aggression or excitement) 2. Unstable medical condition 3. History of uncontrolled seizures 4. Co morbid medical or neurological disorder that can affect structure of the brain. 5. Pregnancy or postpartum state 6. Comorbid substance abuse or dependence 7. Significant neurologic disorder 8. Any contraindication for MRI & TMS 9. Left/mixed Handedness
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Verbal fluency Test scores.Timepoint: Time point 1 (T1)- Baseline Time point 2 (T2)- End of intervention of the study i.e End of 10th session (5DAYS) or termination of the trial for any predefined reasons) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Scale for the Assessment of Positive Symptom (SAPS) 2. Scale for the Assessment of Negative Symptom (SANS) 3. Brief Psychiatric Rating Scale (BPRS). 4. Clinical Global Impressions (CGI) Scale 5. Brief Assessment of Cognition in Schizophrenia (BACS) 6. Social and Occupational Functioning Assessment Scale (SOFAS) 7. NLP (Natural Language Processing) metrics derived from recorded speech interview. 8. Brain magnetic imaging measures (structural image, task based functional images, resting-state functional images, diffusion tensor images, glutamate levels at left anterior temporal cortex from MR spectroscopy) 9. TMS- Electroencephalography measures at Baseline. Timepoint: Time point 1 (T1)- Baseline Time point 2 (T2)- End of intervention of the study i.e End of 10th session (5DAYS) or termination of the trial for any predefined reasons) | — |
Countries
India
Contacts
Public ContactDr Kiran Basawaraj Bagali
NIMHANS (National Institute of Mental Health and Neurosciences)
Outcome results
None listed