A comparative study to assess prophylactic use of atropine V/S glycopyrrolate to attenuate negative hemodynamic effects of propofol and fentanyl under general anaesthesia

Atropine V/S glycopyrrolate to attenuate propofol and fentanyl induced haemodynamics effects under general anaesthesia : A Prospective Randomised Study - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/03/063546

Enrollment

Registered

2024-03-04

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K800- Calculus of gallbladder with acutecholecystitis Health Condition 2: C509- Malignant neoplasm of breast of unspecified site Health Condition 3: C23- Malignant neoplasm of gallbladder Health Condition 4: K318- Other specified diseases of stomach and duodenum

Interventions

Intervention1: General anesthesia: Atropine (0.6mg/ml-1cc) or Glycopyrrolate(0.2mg) will be administered just before induction according to the group assigned and BP, HR, MAP will be recorded (T0) and

Eligibility

Inclusion criteria

Inclusion criteria: 1. ASA Grade I & II

Exclusion criteria

Exclusion criteria: 1. Patients with contraindications of atropine 2. Patients with IHD/CAD 3. Patients with ECG showing tachyarrhythmias 4. Emergency surgeries 5. Mallampati grade III and IV 6. Anticipated difficult airway

Design outcomes

Secondary

Measure	Time frame
To observe the intraoperative complications in both the groups. To observe any postoperative complications related to drug and procedure. Timepoint: till 15 minutes	—

Primary

Measure	Time frame
Atropine V/S glycopyrrolate to attenuate propofol and fentanyl induced haemodynamics effects under general anaesthesia to compare the Hemodynamic variables between both groups.Timepoint: till 15 minutes	—

Countries

India

Contacts

Public ContactAnita pareek

sardar patel medical college bikaner

dranitapareek23@gmail.com09828101281

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026