Health Condition 1: M057- Rheumatoid arthritis with rheumatoid factor without organ or systems involvement
Conditions
Interventions
Intervention1: N- ACETYL CYSTEINE: 600 mg twice a day for 12 weeks
Control Intervention1: Methotrexate,
Hydroxychloroquine: 7.5 mg / week
400 mg / day for 12 weeks
Sponsors
Government Kilpauk Medical College
Eligibility
Inclusion criteria
Inclusion criteria: Newly diagnosed as rheumatoid arthritis within 2 years by ACR criteria and having DAS 28-ESR score more than 3.2 who are not responding to standard therapy
Exclusion criteria
Exclusion criteria: Newly diagnosed Rheumatoid arthritis patients having DAS 28-ESR score less than 3.2 History of Psychiatric illness or drug abuse History of seizure disorder. Known case of hypersensitive to N acetyl cysteine. Pregnant and lactating females History of any autoimmune disease other than rheumatoid arthritis Patient taken biological agent therapy in last 6 months Patients taking N acetyl cysteine for any other cause.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Disease activity assessed using DAS 28 ESR score and CRPTimepoint: at baseline and 12 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| particpants will be assessed by CBC,LFT, RFT,CRP, ESR, RFTimepoint: at baseline , 4 ,8,12, 16 weeks | — |
Countries
India
Contacts
Public ContactDr T Aruna
Government Kilpauk Medical College
Outcome results
None listed