Effect of different modes of anaesthesia, i.e., TIVA using propofol and lignocaine with inhalational agents, on values of VEGF and Tells activity ( T helper cell CD4+ and cytotoxic T cells CD 8 +).

Comparison of efficacy of intravenous anaesthesia with propofol and lignocaine versus inhalational anaesthesia on VEGF level and cytotoxic (CD 8+) and helper T cells (CD 4+) level in patients undergoing ovarian cancer surgery: An open-label randomized control trial. ? - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/03/063519

Enrollment

Registered

2024-03-04

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C569- Malignant neoplasm of unspecifiedovary

Interventions

Intervention1: TIVA (total intravenous anaesthesia) : BIS guided propofol infusion and lignocaine at the dose of 1.5 mg/kg/hr will be used for anaesthesia maintenance. lignocaine infusion will be stop

Eligibility

Inclusion criteria

Inclusion criteria: Female patients aged between 25-65yrs (American society of anaesthesiologist grading I, II,III) undergoing surgery for ovarian cancer will be included.

Exclusion criteria

Exclusion criteria: 1. Patients with ASA grade >3 2. Patients having chronic pain or on any opioid treatment 3. Patients requiring postoperative ventilation support. 4. Any ongoing infection in patient 5. Any other chronic inflammatory condition as RA, inflammatory bowel disease etc. 6. Pre Existing immunodeficiency. 7. Patient with BMI > 35 kg/m2

Design outcomes

Primary

Measure	Time frame
To compare difference in change of post-operative and preoperative VEGF (Day 2 -preoperative) in both the groups.Timepoint: day 2	—

Secondary

Measure	Time frame
To compare changes in level of post-operative and preoperative Tells activity ( T helper cell CD4+ and cytotoxic T cells CD 8 +),) in both groups (Day 2 -Preoperative). To compare the values of VEGF, Tells activity ( T helper cell CD4+ and cytotoxic T cells CD 8 +), in both groups. To compare Glasgow prognostic index and systemic immune inflammation index in both the group at day 2. Timepoint: day 2	—

Measure

Time frame

To compare changes in level of post-operative and preoperative Tells activity ( T helper cell CD4+ and cytotoxic T cells CD 8 +),) in both groups (Day 2 -Preoperative). To compare the values of VEGF, Tells activity ( T helper cell CD4+ and cytotoxic T cells CD 8 +), in both groups. To compare Glasgow prognostic index and systemic immune inflammation index in both the group at day 2. Timepoint: day 2

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Countries

India

Contacts

Public ContactDr Keval Mirani

All India Institute of Medical Sciences, Jodhpur

dr.priyanka_sethi@yahoo.co.in9352206300

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026