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Comparing phenytoin vs saline instillation combined with vacuum therapy in wounds

COMPARISON OF NEGATIVE PRESSURE WOUND THERAPY COMBINED WITH INSTILLATION OF TOPICAL PHENYTOIN VERSUS SALINE IN HEALING OF EXTREMITY ULCERS- A RANDOMIZED CONTROL TRIAL - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/03/063479
Enrollment
140
Registered
2024-03-04
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L088- Other specified local infections of the skin and subcutaneous tissue

Interventions

Intervention1: PHENYTOIN INSTILLATION: All the patients with extremity wounds included in the study will undergo debridement either under local/regional block in minor procedure room or under general

Sponsors

JIPMER Intramural Research Fund
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with extremity ulcer between 18 and 75 yearS

Exclusion criteria

Exclusion criteria: 1.Patients diagnosed with peripheral vascular disease. 2.Acutely ischemic wounds. 3.Wounds with exposed blood vessels. Wounds with undrained abscess.

Design outcomes

Primary

MeasureTime frame
To assess the effect of negative pressure wound closure with topical phenytoin instillation on wound healing measured in terms of time to wound closure and percentage reduction in wound surface areaTimepoint: 14 DAYS—

Secondary

MeasureTime frame
To assess the pathological strength of granulation To assess the microbiological profile of the wound.Timepoint: 14 DAYS—

Countries

India

Contacts

Public ContactYadunand Sriram

JIPMER

drbalak@gmail.com9443617089

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026