Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: NIL: NIL
Control Intervention1: NIL: NIL
Sponsors
All India Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: All patients posted for elective surgeries with an expected anesthetic duration of more than 60 minutes under general anesthesia in the age group of 4-15 years of age who belong to ASA Grade I- III
Exclusion criteria
Exclusion criteria: 1. Patients with hemodynamic instability. 2. Children less than 3 years 3. Patients with severe hepatic and renal dysfunction. 4. High intra-abdominal pressure >15 mm Hg 5. History of adverse reactions to sevoflurane, propofol and other study drugs 6. Neurological disorder. 7. Bowel resection surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| a.Gut microbiota profiling of the enrolled subjects at baseline and on postoperative period to assess the effect of anaesthetic agents. b. To assess metabolic profile (fecal metabolites) of the enrolled subjects at baseline and on postoperative period. Timepoint: 24 hour after surgery and on 7th postoperative day | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Cognition of childrenTimepoint: before surgery, after surgery at 48 hours and at 7 days | — |
Countries
India
Contacts
Public ContactAnju Gupta
All India Institute of Medical Sciences , Delhi
Outcome results
None listed