Can the addition of Hyaluronic acid to Platelet rich plasma decrease the post procedural pain in intra articular injections for osteoarthritis knee?

A single-centric, patient-blinded randomized parallel group non-inferiority study to compare the effectiveness of post-procedural pain relief between Platelet-Rich Plasma (PRP) alone versus PRP with Hyaluronic Acid Supplementation for intra articular OA Knee injections. - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/03/063421

Enrollment

106

Registered

2024-03-01

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M179- Osteoarthritis of knee, unspecified

Interventions

Intervention1: Platelet rich plasma and 90mg Hyaluronic acid: Site-intra articular knee injection Frequency-one injection Drug and Dose- 3ml of platelet rich plasma(PRP) and 90mg of hyaluronic acid in

Eligibility

Inclusion criteria

Inclusion criteria: History of knee joint pain for atleast 3 months and or joint edema and radiographic evidence of mild to moderate OA Knee of KL grading(1,2,3)

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
The mean changes from baseline levels of knee pain as measured using the VAS.Timepoint: 24 hr,72hr,1week and 6weeks	—

Secondary

Measure	Time frame
functional changes in the knee (global perceived effect), patient satisfaction with treatment, changes in analgesics, the incidence of adverse effectsTimepoint: 24 hr,72hr,1week and 6weeks	—

Countries

India

Contacts

Public ContactGautam Das

Daradia the pain clinic

gdas2310@gmail.com09163357246

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026