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"Addition of 5% dextrose around the genicular nerve"- A novice approach to increase the efficacy of regenerative therapy in Osteoarthritis knee.

A single-centric, double-blinded randomized parallel group non-inferiority study to explore the synergistic effectiveness of perineural genicular nerve injection with 5% Dextrose in osteoarthritis knee receiving intra articular Platelet rich Plasma and Hyaluronic Acid. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/03/063419
Enrollment
52
Registered
2024-03-01
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M179- Osteoarthritis of knee, unspecified

Interventions

Intervention1: 5% Dextrose water: Single injection of 2 ml 5% Dextrose around each genicular nerve by perineural approach. Control Intervention1: 0.9% Normal saline: Single injection of 2 ml 0.9% no

Sponsors

NIL
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1) patients willing to take part in the study and aged 50–80 years who presented with chronic knee pain, (i.e., knee pain of moderate or greater intensity on most or all days for = 3 months) 2)Following radiological assessments, radiological tibiofemoral OA (Kellgren-Lawrence grade 2–4 as evaluated by a radiologist

Exclusion criteria

Exclusion criteria: acute knee pain, prior knee surgery, other connective tissue diseases that affected the knee, serious neurological or psychiatric disorders, steroid or hyaluronic acid injection therapy during the previous 3 months, sciatic pain, anticoagulant medication use and platelet count less than 1,50,000 per microliter.

Design outcomes

Primary

MeasureTime frame
The mean changes from baseline levels of knee pain using VASTimepoint: 24hrs, 72hrs, 4, and 8 weeks

Secondary

MeasureTime frame
Functional changes in the knee (global perceived effect), patient satisfaction with treatment, changes in analgesics, the incidence of adverse effects, and the proportion of successful respondersTimepoint: 24hrs, 72hrs, 4, and 8 weeks

Countries

India

Contacts

Public ContactGautam Das

Daradia the pain clinic

gdas2310@gmail.com09163357246

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026