The effect of laparoscopic sleeve gastrectomy on non alcoholic fatty liver disease using magnetic resonance imaging proton density fat fraction in patients with morbid obesity

To study the effect of laparoscopic sleeve gastrectomy on non-alcoholic fatty liver disease using magnetic resonance imaging- proton density fat fraction in morbid obesity patients. - Nil

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/02/063362

Enrollment

Registered

2024-02-29

Start date

Unknown

Completion date

Unknown

Last updated

2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E669- Obesity, unspecified

Interventions

Intervention1: Laparoscopic Sleeve Gastrectomy: MRI PDFF will be done one week prior to surgery and 3 months after Laparoscopic Sleeve Gastrectomy

Eligibility

Inclusion criteria

Inclusion criteria: Morbidly obese individuals with BMI more than 37.5; Morbidly obese individuals with BMI more than 32.5 with comorbidities like diabetes mellitus, hypertension, obstructive sleep apnea, non alcoholic fatty liver, hyperlipidemia.

Exclusion criteria

Exclusion criteria: Patients having 1. Patients who underwent previous bariatric surgery 2. Any patient with contraindication for MRI 3. Diagnosed case of chronic liver disease. 4. Hepatotoxic medications.

Design outcomes

Primary

Measure	Time frame
Change in percentage hepatic fat fraction and proportion of patients of NAFLD shifting to low grade on MRI-PDFF 3 months after laparoscopic sleeve gastrectomy.Timepoint: One week prior to surgery and 3 months after surgery	—

Secondary

Measure	Time frame
1. Change in the serum level of Adiponectin, leptin, soluble leptin receptors before and 3months after laparoscopic sleeve gastrectomy in patients of morbid obesity. 2. Correlation between changes in percentage hepatic fat fraction on MRI with change in serum level of Adiponectin, Leptin, soluble leptin receptors before and 3 months after laparoscopic sleeve gastrectomy. 3. Correlation between percentage hepatic fat fraction on MRI-PDFF with percentage excess weight loss 3 months after Laparoscopic Sleeve Gastrectomy.Timepoint: Before and 3 months after surgery	—

Measure

Time frame

1. Change in the serum level of Adiponectin, leptin, soluble leptin receptors before and 3months after laparoscopic sleeve gastrectomy in patients of morbid obesity. 2. Correlation between changes in percentage hepatic fat fraction on MRI with change in serum level of Adiponectin, Leptin, soluble leptin receptors before and 3 months after laparoscopic sleeve gastrectomy. 3. Correlation between percentage hepatic fat fraction on MRI-PDFF with percentage excess weight loss 3 months after Laparoscopic Sleeve Gastrectomy.Timepoint: Before and 3 months after surgery

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Countries

India

Contacts

Public ContactVandana

Lady Hardinge Medical College

gyansaurabh@yahoo.com9873298420

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026