Effects of naval cord squeezing in small babies not breathing at birth

Hemodynamic Effects of Umbilical Cord Milking versus Early Cord Clamping in Non-vigorous Intrauterine Growth Restricted Neonates: A Randomized Controlled Trial - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/02/063323

Enrollment

Registered

2024-02-29

Start date

Unknown

Completion date

Unknown

Last updated

2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: P059- Newborn affected by slow intrauterine growth, unspecified

Interventions

Intervention1: Umbilical cord milking: After complete delivery, the uncut umbilical cord will be grasped gently. Approximately 20 cm of the cord will be squeezed at a speed of 10cm/sec towards the inf

Eligibility

Inclusion criteria

Inclusion criteria: Antenatally detected intrauterine growth restricted neonates more than 28-weeks gestation who are non-vigorus at birth.

Exclusion criteria

Exclusion criteria: 1. Neonates born to mother with a. Hemodynamic instability b. Placental previa/abruption c. Postpartum hemorrhage d. Multiple gestation: Monochorionic twins. e. Rh sensitized pregnancy 2. Major congenital malformation 3. Fetal hydrops

Design outcomes

Primary

Measure	Time frame
Left ventricular output (mL/kg/min) by bedside echocardiographyTimepoint: At 24 ± 2 hours of life	—

Secondary

Measure	Time frame
1. Left atrial to aortic root ratio 2. Left ventricle dimensions for fractional shortening 3. Right ventricular output 4. Tricuspid annular plane systolic excursion 5. Peak velocities of the E wave and A wave and E by A ratio 6. E wave deceleration time 7. Isovolumic relaxation time 8. Superior vena cava blood flow 9. Patent ductus arteriosus, patent foramen ovale 10. Pulmonary arterial pressure by tricuspid regurgitant jet if present 11. Mean blood pressures 12. Venous hematocrit 13. Incidence of significant neonatal hyperbilirubinemia and duration of phototherapy during hospital stay 14. Incidences of polycythemia, intraventricular hemorrhage, respiratory distress requiring respiratory support, feeding intolerance and necritizing enetrocolitis (Modified Bell Stage II and beyond) during hospital stay 15. Final outcome 16. Duration of hospital stay Timepoint: At 24 ± 2 hours of life	—

Measure

Time frame

1. Left atrial to aortic root ratio 2. Left ventricle dimensions for fractional shortening 3. Right ventricular output 4. Tricuspid annular plane systolic excursion 5. Peak velocities of the E wave and A wave and E by A ratio 6. E wave deceleration time 7. Isovolumic relaxation time 8. Superior vena cava blood flow 9. Patent ductus arteriosus, patent foramen ovale 10. Pulmonary arterial pressure by tricuspid regurgitant jet if present 11. Mean blood pressures 12. Venous hematocrit 13. Incidence of significant neonatal hyperbilirubinemia and duration of phototherapy during hospital stay 14. Incidences of polycythemia, intraventricular hemorrhage, respiratory distress requiring respiratory support, feeding intolerance and necritizing enetrocolitis (Modified Bell Stage II and beyond) during hospital stay 15. Final outcome 16. Duration of hospital stay Timepoint: At 24 ± 2 hours of life

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Countries

India

Contacts

Public ContactPoonam Singh

All India Institute of Medical Sciences, Rishikesh

bhagyashree.pr41@gmail.com8527106059

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jul 10, 2026