To study the effect of a drug named Dexmedetomidine which is administered through nose before insertion of tube through windpipe for management of anaesthesia

The effect of Intranasal Dexmedetomidine on Hemodynamic responses during Double Lumen Tube insertion- A Randomized Controlled Trial - Nil

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/02/063320

Enrollment

Registered

2024-02-29

Start date

Unknown

Completion date

Unknown

Last updated

2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J984- Other disorders of lung

Interventions

Intervention1: Intranasal Dexmedetomidine group: Intranasal Dexmedetomidine-1mcg/kg administered 45 minutes prior to induction and Hemodynamic responses To Laryngoscopy and Endobronchial intubation wi

Eligibility

Inclusion criteria

Inclusion criteria: Patients undergoing elective lung surgery including pulmonary lobectomy, pneumonectomy, metastasectomy, decortication, etc who require Left sided DLT placement ASA Physical status I to III

Exclusion criteria

Exclusion criteria: 1. Patients with difficult airway 2. Surgeries requiring Right sided Double Lumen Tube insertion 3. Uncontrolled hypertensives 4. Heart disease with ejection fraction less than 40% 5. Body mass index more than 35 kg/ m2 6. History suggestive of sensitivity to drugs used during the study 7. Patients with bradycardia (heart rate 8. Nasal pathology 9. History of reactive airway disease 10. Hepatic or Renal impairment 11. Pregnancy

Design outcomes

Primary

Measure	Time frame
To compare the Hemodynamic responses between Dexmedetomidine and Placebo given in addition to drugs used in our current standard of care during laryngoscopy and DLT insertionTimepoint: 1 hour	—

Secondary

Measure	Time frame
1. To assess the requirement of additional anaesthetic drugs ( fentanyl, propofol) in order to maintain the hemodynamics within 20% of baseline values during Laryngoscopy and DLT insertion 2. To assess the incidence of hypotension and bradycardia during drug administration and during laryngoscopy and DLT insertion 3. To assess the intraoperative requirement of rescue medication ( phenylephrine, ephedrine) to treat the hypotension and bradycardiaTimepoint: 1 hour	—

Measure

Time frame

1. To assess the requirement of additional anaesthetic drugs ( fentanyl, propofol) in order to maintain the hemodynamics within 20% of baseline values during Laryngoscopy and DLT insertion 2. To assess the incidence of hypotension and bradycardia during drug administration and during laryngoscopy and DLT insertion 3. To assess the intraoperative requirement of rescue medication ( phenylephrine, ephedrine) to treat the hypotension and bradycardiaTimepoint: 1 hour

—

Countries

India

Contacts

Public ContactBalaji Kuppuswamy

Christian Medical College

balooswamy@gmail.com7406777127

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026