Health Condition 1: T600- Toxic effect of organophosphate and carbamate insecticides
Conditions
Interventions
Intervention1: Magnesium sulphate: dose 4gm mgs04 diluted in 50 ml NS OVer 30 min IV
Control Intervention1: not applicable: not applicable
Sponsors
JLN Medical College and Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Patients arriving in the emergency OPD with history of OPC consumption and clinical features of cholinergic toxidrome of typical organophosphorus compound poisoning.
Exclusion criteria
Exclusion criteria: Doubtful history Poisoning with unknown compound Treatment initiated before admission Patient refusal to consent Patient sensitive /allergic to any of the study drugs. Cardiovascular disease patients(1-and2-degree heartblock) Severe hepatic and renal disease. History of epilepsy or bleeding tendencies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To study the efficacy of magnesium sulphate as adjuvant to the standard therapy (Atropine and oximes) in reducing morbidity and mortality.Timepoint: zero time at time of admission 15 min. 30 min. 45 min. 1 hour 1.5 hour 2 hour 4 hour 6 hour 8 hour 12 hour 16 hour 20 hour 24 hour | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess the requirement of atropine. To compare the need for intubation and ventilation and ICU Stay. To calculate the duration of hospital stay Timepoint: zero time at the time of admission 5 min 10 min 15 min 45 min 1 hour 1.5 hour 2 hour 4 hour 6 hour 8 hour 12 hour 16 hour 20 hour 24 hour | — |
Countries
India
Contacts
Public ContactDr Naveen Singh
J.L.N. Medical College Ajmer
Outcome results
None listed