Comparison between intravenous lignocaine and nebulization with lignocaine in suppressing response to laryngoscopy and intubation

Lignocaine Nebulization versus Intravenous Lignocaine to suppress the hemodynamic response to Laryngoscopy and Tracheal Intubation: A Comparative Study - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/02/063279

Enrollment

Registered

2024-02-29

Start date

Unknown

Completion date

Unknown

Last updated

2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Intravenous lignocaine and nebulization with lignocaine: It will be a double-blind clinical trial. The study participants and the researcher will be blinded of the intervention that the

Eligibility

Inclusion criteria

Inclusion criteria: 1. patient giving consent 2. all patients aged 18-45yrs 3. ASA grade 1&2 4. both genders 5.hemodynamically stable patients 6. patients undergoing elective surgical procedures under GA 7. patient not receiving any vasoactive drugs.

Exclusion criteria

Exclusion criteria: 1. Patient refusal for giving consent 2. Patient who already received lignocaine by any route. 3. Hypersensitivity to lignocaine. 4. History of convulsions. 5. Patient receiving vasoactive drug support. 6. Patient on mechanical ventilation with endotracheal or tracheostomy tube. 7. H/O COPD, cardiovascular disease, psychiatric disorders and liver disorders. 8. Patients with anticipated difficult airway. 9. Patients having history of laryngeal, tracheal surgery or any pathology.

Design outcomes

Primary

Measure	Time frame
To study the haemodynamic response during laryngoscopy and endotracheal intubation.Timepoint: 20-30 minutes	—

Secondary

Measure	Time frame
1.To evaluate the complication associated with nebulization vs intravenous lignocaine. 2.To evaluate the suppression of arrhythmia if any during laryngoscopy and intubation. 3. To compare the suppression of autonomic nervous system associated with nebulization vs intravenous lignocaine.Timepoint: 20 minutes	—

Countries

India

Contacts

Public ContactDr Geeta Bhandari

Government medical college Haldwani

bhandari_geetantl@rediffmail.com8650655556

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026