“COMPARISON BETWEEN GABAPENTIN ALONE AS PREMEDICATION VERSUS COMBINATION OF GABAPENTIN AND NORTRIPTYLINE AS PREMEDICATION ON INTRAOPERATIVE HEMODYNAMICS AND POSTOPERATIVE PAIN RELIEF IN PATIENTS UNDERGOING SURGERIES UNDER GENERAL ANESTHESIA ?

“COMPARISON OF GABAPENTIN VERSUS GABAPENTIN AND NORTRIPTYLINE AS PREMEDICATION ON PERIOPERATIVE HEMODYNAMICS AND POSTOPERATIVE ANALGESIA IN PATIENTS UNDERGOING SURGERIES UNDER GENERAL ANESTHESIA ? - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/02/063251

Enrollment

100

Registered

2024-02-28

Start date

Unknown

Completion date

Unknown

Last updated

2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Tab Nortriptylin + Tab Gabapentin: Tab Nortriptylin 25mg 8 hours before surgery + Tab Gabapentin 300mg 3- 4 hours before surgery These drugs will be administered as premedication in pat

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients age between 18 – 60 years 2. Patients with weight above 50kgs. 3. Patients scheduled for elective surgery with an anticipated duration of 2-3 hours under general anesthesia. 4. Patients giving informed written consent. 5.Patients belonging to ASA I, II

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Observation and comparison of perioperative hemodynamic parameters between two groups (Blood pressure, Pulse rate, SpO2)Timepoint: To assess hemodynamic parameters at following intervals BASELINE During intubation 5 mins 10 mins 15 mins 20 mins 25 mins 30 mins 45 mins 60 mins 1.5 hours 2 hours 2.5 hours 3 hours and postoperatively	—

Secondary

Measure	Time frame
• Sedation & anxiolytic property of the drug combination Timepoint: baseline - before induction 10 mins after extubation;consumption of sevoflurane intraoperativelyTimepoint: During intubation 5 mins after intubation 10 mins 15 mins 20 mins 25 mins 30 mins 45 mins 60 mins 1.5 hours 2 hours 2.5 hours 3 hours ;post op analgesiaTimepoint: Immediate Post-op 2 hours 4 hours 6 hours 8 hours 12 hours 24 hours ;anti emetic property of the drugTimepoint: immediate post op 30 mins 1 hour 2 hours 3 hours 4 hours	—

Measure

Time frame

• Sedation & anxiolytic property of the drug combination Timepoint: baseline - before induction 10 mins after extubation;consumption of sevoflurane intraoperativelyTimepoint: During intubation 5 mins after intubation 10 mins 15 mins 20 mins 25 mins 30 mins 45 mins 60 mins 1.5 hours 2 hours 2.5 hours 3 hours ;post op analgesiaTimepoint: Immediate Post-op 2 hours 4 hours 6 hours 8 hours 12 hours 24 hours ;anti emetic property of the drugTimepoint: immediate post op 30 mins 1 hour 2 hours 3 hours 4 hours

—

Countries

India

Contacts

Public ContactDr Soumya Rohit

BANGLORE MEDICAL COLLEGE AND RESEARCH INSTITUTE

drsoumyarohit@gmail.com9611106641

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026