The effect of propofol based anaesthesia versus sevoflurane based anaesthesia on tumour marker levels after gall bladder cancer surgery.

A Randomised Controlled Trial of Effect Of Propofol Based Total Intravenous Anaesthesia Versus Sevoflurane Based Inhalational Anaesthesia on VEGF-C And TGF-beta Levels after Radical Gall Bladder Cancer Surgery. - Nil

Status

Recruiting

Phases

Phase 4

Study type

Observational

Source

CTRI

Registry ID

CTRI/2024/02/063208

Enrollment

Registered

2024-02-27

Start date

Unknown

Completion date

Unknown

Last updated

2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C23- Malignant neoplasm of gallbladder

Interventions

Intervention1: Propofol based total Intravenous Anaesthesia group: Anesthesia will be maintained using propofol based total intravenous anaesthetic drugs during intraoperative period (3-5 Hours). Cont

Eligibility

Inclusion criteria

Inclusion criteria: i. Adult patients 18 years and above ii. Patients posted for radical cholecystectomy surgeries iii. American Society of Anesthesiologists (ASA) grade I-II

Exclusion criteria

Exclusion criteria: i. Patients with severe uncontrolled hepatic, renal, pulmonary, CNS or cardiac diseases ii. Pregnancy and lactation iii. Patients posted for revision cholecystectomy surgery iv. History of allergy to eggs or study drugs v. Patient refusal

Design outcomes

Primary

Measure	Time frame
Measurement of angiogenic serum VEGF-C and TGF-ß levels in the blood.Timepoint: 2 hours prior to induction of anaesthesia and 24 hours after the surgery.	—

Secondary

Measure	Time frame
Length of hospital stayTimepoint: After surgery and upto discharge or death.;Length of intensive care unit stayTimepoint: After the admission into intensive care unit to discharge or death.;Morbidity as per Clavien-Dindo classificationTimepoint: upto 30 days after surgery;Postoperative nausea and vomitingTimepoint: After admission into recovery room and upto 24 hours after surgery;Postoperative pain scores and use of opioids for pain reliefTimepoint: After admission into recovery room and upto 24 hours after surgery;Readmission in the hospitalTimepoint: after discharge upto 30 days after surgery;Recurrent free survival and overall survivalTimepoint: One year after the surgery	—

Measure

Time frame

Length of hospital stayTimepoint: After surgery and upto discharge or death.;Length of intensive care unit stayTimepoint: After the admission into intensive care unit to discharge or death.;Morbidity as per Clavien-Dindo classificationTimepoint: upto 30 days after surgery;Postoperative nausea and vomitingTimepoint: After admission into recovery room and upto 24 hours after surgery;Postoperative pain scores and use of opioids for pain reliefTimepoint: After admission into recovery room and upto 24 hours after surgery;Readmission in the hospitalTimepoint: after discharge upto 30 days after surgery;Recurrent free survival and overall survivalTimepoint: One year after the surgery

—

Countries

India

Contacts

Public ContactDr Emelda Josephina

Tata Memorial Hospital

emeldaj23@gmail.com9745580785

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026