Formulate and evaluate a gel which improves healing of tooth extraction wounds in diabetic patients.

Formulation and evaluation of a gel comprising an antifibrinolytic (Tranexamic Acid) in combination with an antibiotic (Doxycycline) after tooth extraction in diabetic patients - A Randomized Controlled Trial - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/02/063198

Enrollment

Registered

2024-02-27

Start date

Unknown

Completion date

Unknown

Last updated

2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K029- Dental caries, unspecified

Interventions

Intervention1: TRANEXAMIC ACID AND DOXYCYCLINE GEL: Tranexamic acid (5%) - antifibrinolytic agent Doxycycline (3%) – antibiotic Carbopol 971PNF – gelling agent Glycerin – solvent Propyl paraben – p

Eligibility

Inclusion criteria

Inclusion criteria: Patients with known history of diabetes whose random blood sugar is within the normal limits. Patients who are willing for treatment. Patients who are willing to give consent to participate in the study. Patients with no significant medical history. (ASA I and ASA II).

Exclusion criteria

Exclusion criteria: Patients with significant infections were excluded from this study. Patients who are not willing for treatment. Patients who are not willing to give consent to participate in the study. Patients with significant medical history (ASA III and ASA IV). Pregnant and lactating patient. Patient having history of allergies to any medications.

Design outcomes

Primary

Measure	Time frame
to evaluate the wound healing activity of a gel comprising tranexamic acid and doxycycline after tooth extraction in diabetic patientsTimepoint: on the day of tooth extraction, 3rd day, 7th day and one month	—

Secondary

Measure	Time frame
evaluation the efficacy of the gel in prevention of dry socket after tooth extraction in diabetic patients. evaluation of the role of the gel in reduction of trismus after tooth extraction in diabetic patients. evaluate whether the gel reduces incidence of infection after tooth extraction in diabetic patients. evaluate whether the gel reduces incidence of pain after tooth extraction in diabetic patients. Timepoint: evaluation the efficacy of the gel in prevention of dry socket after tooth extraction in diabetic patients. evaluation of the role of the gel in reduction of trismus after tooth extraction in diabetic patients. evaluate whether the gel reduces incidence of infection after tooth extraction in diabetic patients. evaluate whether the gel reduces incidence of pain after tooth extraction in diabetic patients.	—

Measure

Time frame

evaluation the efficacy of the gel in prevention of dry socket after tooth extraction in diabetic patients. evaluation of the role of the gel in reduction of trismus after tooth extraction in diabetic patients. evaluate whether the gel reduces incidence of infection after tooth extraction in diabetic patients. evaluate whether the gel reduces incidence of pain after tooth extraction in diabetic patients. Timepoint: evaluation the efficacy of the gel in prevention of dry socket after tooth extraction in diabetic patients. evaluation of the role of the gel in reduction of trismus after tooth extraction in diabetic patients. evaluate whether the gel reduces incidence of infection after tooth extraction in diabetic patients. evaluate whether the gel reduces incidence of pain after tooth extraction in diabetic patients.

—

Countries

India

Contacts

Public ContactDR G ANAND

GOVERNMENT DENTAL COLLEGE AND HOSPITAL

dr.kavitawadde@gmail.com09004799405

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026