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Comparative study of the effect of Dexmedetomidine-Lignocaine based Opioid free anaesthesia versus Standard General Anaesthesia on inflammatory markers in patients undergoing TAH

Evaluation of inflammatory response of Dexmedetomidine-Lignocaine based opioid free anaesthesia in patients undergoing Total Abdominal Hysterectomy - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2024/02/063028
Enrollment
30
Registered
2024-02-22
Start date
Unknown
Completion date
Unknown
Last updated
2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: O- Medical and Surgical

Interventions

Control Intervention1: Dexmedetomidine-Lignocaine based opioid free anaesthesia.: Opioid free anaesthesia given to the patient throughout the course of surgery. loading dose of IV Dexmedetomidine at 1

Sponsors

Maulana Azad Medical College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA GRADE 1-2

Exclusion criteria

Exclusion criteria: Any cardiac, renal or hepatic diseases Patients having acute infections or hepatic illnesses. BMI > 30 kg/square metres. History of allergies to therapeutic drugs used in the study.

Design outcomes

Primary

MeasureTime frame
The change of plasma cytokine levels of IL6 and TNF alpha from baseline to immediately after the end of surgery and 24 hours after the end of surgery.Timepoint: Baseline to immediately after the surgery and 24 hours after the end of surgery.—

Secondary

MeasureTime frame
The change in inflammatory bio markers : Procalcitonin, C-reactive protein, D-dimer, from baseline to immediately after the surgery & 24 hours after the end of surgery.Timepoint: Duration of post operative analgesia.—

Countries

India

Contacts

Public ContactKirti Mehra

Maulana Azad Medical College

drbhartitaneja@gmail.com9968604221

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026