Health Condition 1: G248- Other dystonia
Conditions
Interventions
Intervention1: Levodopa: Titration 2 weeks Levodopa and Carbidopa 10mg (1./2 tab tdsx 1 week and 1 tab tdsx 1week and half abs in less in 15 years and 2 tab tds 15 years of age Vs placebo
Control Int
Sponsors
Dr Jayantee Kalita
Eligibility
Inclusion criteria
Inclusion criteria: Baseline 4 weeks. Age more than 8 years, BFMDR score more than 10. Baseline blood investigation followed by 1: 1 randomization. Levodopa Titration for 2 weeks and maintained for 12 weeks
Exclusion criteria
Exclusion criteria: Patients with head injury, stroke, tumor, malignancy, chronic renal failure, decompensated liver disease, perinatal hypoxia, HIV, organ transplantation, pregnancy and those receiving antipsychotics, corticosteroid, antiemetic and structural brain lesion on MRI not explainable by WD will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement in BFMDRS by 50% will be considered improvedTimepoint: 4 weeks and 12 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement in neurological severity scale, NPI & DOSS, UWRS, adverse effects.Timepoint: at 3 months | — |
Countries
India
Contacts
Public ContactDr Jayantee Kalita
SGPGIMS Lucknow
Outcome results
None listed