A study to determine effects of magnesium sulphate with Bupivacaine hydrochloride in spinal anaesthesia.

A prospective randomized study to evaluate the effects of intrathecal magnesium sulphate as an adjuvant to Bupivacaine hydrochloride in spinal anaesthesia. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/02/062867

Enrollment

100

Registered

2024-02-19

Start date

Unknown

Completion date

Unknown

Last updated

2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K40-K46- Hernia Health Condition 2: M15-M19- Osteoarthritis Health Condition 3: N20-N23- Urolithiasis

Interventions

Intervention1: Addition of Intrathecal Magnesium Sulphate with bupivacaine Heavy in spinal anesthesia.: 100 patients will be divided in two groups : (A) Group C (Control group)(50 patients): Inj. Bup

Eligibility

Inclusion criteria

Inclusion criteria: 1. Adult patients ranging from 18-65 years of age 2. Patients undergoing infra-umbilical surgeries 3. Patients belonging to ASA grade 1 and 2

Exclusion criteria

Exclusion criteria: 1. Patients refusal, uncooperative patients or children 2. Patients with hepatic, renal, cardiac or respiratory problems. 3. Patients with localised site infections 4. Haematological, bleeding disorders and coagulopathies. 5. Known allergy to magnesium sulphate or other study drugs.

Design outcomes

Primary

Measure	Time frame
Prolongation of the onset and time to reach the highest level of sensory and motor blockade in spinal anesthesia.Timepoint: 1. Onset of Motor blockade after injection of drug intrathecally 2. Onset, highest level and duration of sensory blockade after injection of drug intrathecally 3. Hemodynamic stability at 0min, and then every 30 mins till end of surgery. 4. Time of requirement of rescue analgesic in post-operative period.	—

Measure

Time frame

Prolongation of the onset and time to reach the highest level of sensory and motor blockade in spinal anesthesia.Timepoint: 1. Onset of Motor blockade after injection of drug intrathecally 2. Onset, highest level and duration of sensory blockade after injection of drug intrathecally 3. Hemodynamic stability at 0min, and then every 30 mins till end of surgery. 4. Time of requirement of rescue analgesic in post-operative period.

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Secondary

Measure	Time frame
An easily available, inexpensive adjuvant to increase & improve spinal anesthesia profile.Timepoint: 1. 1. Onset of Motor blockade after injection of drug intrathecally 2. Onset, highest level & duration of sensory blockade after injection of drug intrathecally 3. Hemodynamic stability at 0min, & then every 30 mins till end of surgery. 4. Time of requirement of rescue analgesic. 5.Cost effectiveness 6. Availability	—

Measure

Time frame

An easily available, inexpensive adjuvant to increase & improve spinal anesthesia profile.Timepoint: 1. 1. Onset of Motor blockade after injection of drug intrathecally 2. Onset, highest level & duration of sensory blockade after injection of drug intrathecally 3. Hemodynamic stability at 0min, & then every 30 mins till end of surgery. 4. Time of requirement of rescue analgesic. 5.Cost effectiveness 6. Availability

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Countries

India

Contacts

Public ContactAnupama Kumari

Smt BK Shah Medical Institute & Research Centre, Piparia

aanupama.kumary@gmail.com9909722777

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026