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To assess the effectiveness of different antibiotics in lung and blood infections caused by carbapenem resistant bacteria

A retrOspective, multi-centre study to evalUate the effecTiveness of different antibiotics/ Combinations being used in patients with bloOd stream infection and/ or hospital acquired pneuMonia caused by CRE (Klebsiella pneumoniae, Escherichia coli), CRAB & CRPA. - OUTCOME

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2024/02/062846
Enrollment
3000
Registered
2024-02-19
Start date
Unknown
Completion date
Unknown
Last updated
2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: A415- Sepsis due to other Gram-negativeorganisms

Interventions

Intervention1: NA: NA

Sponsors

Dr Deepak Govil
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Adult more than 18 years of age with confirmed culture based diagnosis of hospital acquired pneumonia (HAP) (pneumonia developing at least 48 hours after hospital admission) and / or blood stream infection caused by CRE (Klebsiella pneumoniae, Escherichia coli) CRAB & CRPA Received antibiotic mono and or combination therapy for at-least 48 hours as per clinician’s discretion

Exclusion criteria

Exclusion criteria: Culture positive from any site other than blood stream/ pneumonia. Any organism other than CRE (Klebsiella pneumoniae, Escherichia coli), CRAB & CRPA isolated within 14 days of initiation/ EOT of antibiotic therapy

Design outcomes

Primary

MeasureTime frame
1. Clinical outcomes of patient with BSI 2.Clinical outcomes of patient with HAP 3.Clinical outcomes of patient with HAP plus BSI 4.Microbiological outcome in patients with BSI 5.Microbiological outcome in patients with HAP 6.Microbiological outcome in patients with HAP plus BSITimepoint: Day 7 and day 14 or EOT from the initiation of antibiotic mono-/ combination therapy—

Secondary

MeasureTime frame
1. Duration of invasive mechanical ventilation (hours) 2. Duration of vasopressor requirement (hours) 3. Need for RRT (Yes/No) 4. Length of hospital stay 5. Length of ICU stay 6. ICU outcome 7. Hospital outcome Timepoint: 7 days and 14 days or end of treatment—

Countries

India

Contacts

Public ContactDr Deepak Govil

Medanta, The Medicity, Gurgaon

drdeepak_govil@yahoo.co.in9818056688

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026