To study and compare the effect of preoperative nebulized Magnesium sulphate versus Lignocaine in reducing the incidence of post-operative sore throat in patients undergoing surgery under general anaesthesia

To study and compare the effect of preoperative nebulized Magnesium sulphate versus Lignocaine in reducing the incidence of post-operative pharyngo-laryngeal complications in patients undergoing surgery under general anaesthesia with cuffed Endotracheal tube - A prospective triple blind randomised control trial - NIL

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/02/062836

Enrollment

Registered

2024-02-19

Start date

Unknown

Completion date

Unknown

Last updated

2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Comparison of Magnesium sulfate and lignocaine in reducing pharyngolaryngeal complications: Patients are randomly selected and nebulized with Magnesium sulfate 250mg and Lignocaine 100

Eligibility

Inclusion criteria

Inclusion criteria: ASA class I-II BMI 18.5-29.9 Undergoing elective surgeries requiring general anaesthesia with cuffed ETT of duration 60-120 minutes

Exclusion criteria

Exclusion criteria: Patients refusal for participation in study,hemodynamically unstable pt,history of hypersensitivity to drug used,history of active or recent URTI(last 6 weeks),trauma during intubation,patients on analgesics or steroids

Design outcomes

Primary

Measure	Time frame
To evaluate & compare the effectiveness of nebulized Magnesium sulfate & Lignocaine in: a.Extubation quality score using 5 points extubation quality score. b.Post extubation airway related adverse effects like cough,sore throat,hoarseness.Timepoint: 2 hours,6 hours,12 hours, 24 hours, 48 hours	—

Secondary

Measure	Time frame
1.To access the hemodynamic parameter during surgery & extubation. 2.To access the airway dynamics during surgery & extubation. 3.To study side effect of study drug if any. 4.Patient satisfaction score.Timepoint: 2 hours 6 hours 12 hours 24 hours 48 hours	—

Countries

India

Contacts

Public ContactSupriya

Dr Rajendra Prasad Government Medical CollegeTanda Kangra Himachal Pradesh

bhanurpgmc@gmail.com9418016807

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026