A0 study to assess safety and effectiveness of carbetocin vs oxytocin after delivery of baby in cesarean section to prevent excessive bleeding

A double blinded randomized controlled study to assess safety and effectiveness of carbetocin vs oxytocin during active management of third stage, for prevention of PPH in patients undergoing cesarean section - nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/02/062831

Enrollment

240

Registered

2024-02-19

Start date

Unknown

Completion date

Unknown

Last updated

2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O82- Encounter for cesarean delivery without indication

Interventions

Intervention1: CARBETOCIN: 100mcg of IV Carbetocin slowly over one minute, during active management of third stage of labour. Blood loss, need for additional uterotonics ,side effects will be noted fo

Eligibility

Inclusion criteria

Inclusion criteria: willing to participate gestational age 36 weeks-41 weeks patients undergoing cesarean section

Exclusion criteria

Exclusion criteria: hypertensive pre eclampsia eclampsia ante partum hemorrhage bleeding disorders thrombocytopenia blood coagulation abnormalities cardiovascular disorders epilepsy asthma migraine renal disease liver disease general anesthesia retained placenta placenta accreta placenta previa previous pph grand multipara fibroid with pregnancy prolonged labour hypersensitivity to oxytocin or carbetocin traumatic pph

Design outcomes

Primary

Measure	Time frame
TO compare the safety and efficacy of carbetocin with oxytocin to prevent PPH during active management of third stage of labour.Timepoint: blood loss assesment intraoperatively,at 1st hour, 2nd hour post partum, 8th hour, 14th hour, 20th hour, 26th hour.	—

Secondary

Measure	Time frame
To compare adverse effects among both groups.Timepoint: adverse effects noted intraoperatively,at 1st hour, 2nd hour post partum, 8th hour, 14th hour, 20th hour, 26th hour.;To compare the requirement for additional uterotonics in both groupsTimepoint: need for additional uterotonics assesed intraoperatively,at 1st hour, 2nd hour post partum, 8th hour, 14th hour, 20th hour, 26th hour.	—

Countries

India

Contacts

Public ContactRAJANI SOMANATHAN

siddaganga medical college and research institute

kuttu2412@gmail.com8606605516

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026