Comparison of two different drugs in attenuating the pressor response to laryngoscopy.

Comparison of sublingual nitroglycerine spray and oral lignocaine spray in attenuating the pressor response to laryngoscopy: A randomised controlled trial. - NIL

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/02/062801

Enrollment

100

Registered

2024-02-19

Start date

Unknown

Completion date

Unknown

Last updated

2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Nitroglycerin: 0.4mg Sublingual spray Intervention2: Lignocaine: 10% oral spray Control Intervention1: Not applicable: Not applicable

Eligibility

Inclusion criteria

Inclusion criteria: Elective surgery under general anaesthesia, ASA grade 1 and 2, Body weight 45-85 kg

Exclusion criteria

Exclusion criteria: Pregnant women, Anticipated difficult airway, nasotracheal intubation, allergy to general anaesthetic drugs, inability to give consent precluding to language barrier, patient refusal

Design outcomes

Primary

Measure	Time frame
To observe changes in heart rate between the two study groupsTimepoint: Heart rate before induction, 1 min, 3 min, 5 min & 10 min after laryngoscopy	—

Secondary

Measure	Time frame
To observe changes in systolic blood pressure, diastolic blood pressure & mean arterial pressureTimepoint: systolic blood pressure, diastolic blood pressure & mean arterial pressure before induction, 1min, 3 min, 5 min and 10 min after laryngoscopy	—

Countries

India

Contacts

Public ContactDr Radhakrishnan

Sri Venkateshwaraa Medical College Hospital And Research Centre

rkpuduvai@gmail.com8825778958

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026