Health Condition 1: M249- Joint derangement, unspecified
Conditions
Interventions
Intervention1: Ketofol (ketamine + propofol in ratio of 1:2): Intravenous ketofol Infusion (will be prepared by adding 4.5 mL of ketamine (225 mg
50 mg/ mL) , 45 mL of 1% propofol (450 mg
10 mg/mL) and 0.5 ml of normal saline, titrated to maintain BIS between 40-60 intraoperatively
Control Intervention1: Propofol: Intravenous propofol infusion (100-150mcg/kg/min) titatred to maintain
Sponsors
Institute of Neurosciences Kolkata
Eligibility
Inclusion criteria
Inclusion criteria: Aged 18–65 years 2. Either gender 3. ASA grade I and II 4. Scheduled for elective spinal instrumentation surgeries under TIVA
Exclusion criteria
Exclusion criteria: Patient refusal. 2. Patients with hypersensitivity to any of the study drugs 3. Patients with BMI >30 kg/m2 4.ASA grade > II 5. Patients with significant cardiac disease, COPD and restrictive lung disease 6. Patients with significant renal or hepatic impairment 7. Patients with CV junction anomalies and all cervical spinal procedures 8. Redo surgery 9. Deformity corrective surgeries ( like scoliosis) 10. Patients on medications for chronic pain. 11. Patients with neuropsychiatric disorders 12. Duration of surgery more than 4 hours
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate and compare intra and post-operative hemodynamic effects of ketofol infusion versus propofol infusion in patients undergoing spinal instrumentation procedures under total intravenous anaesthesia [TIVATimepoint: Before induction Post intubation at 1 min On incision 15 min 30 min 45 min 1 hr 1 hr 15 min 1 hr 30 min 1 hr 45 min 2 hr 2 hr 15 min 2 hr 30 min 2 hr 45 min 3 hr 3 hr 15 min 3 hr 30 min 3 hr 45 min 4 hr At extubation 1 hr post operative 2 hr post operative 4 hr post operative | — |
Secondary
| Measure | Time frame |
|---|---|
| Compare the total amount of propofol consumptionTimepoint: In the intraoperative period;Evaluate and compare the awakening timeTimepoint: During extuabtion;Incidence of PONVTimepoint: In the postoperative period;Postoperative analgesia requirementTimepoint: In the postoperative period;Requirements of rescue analgesiaTimepoint: In the postoperative period | — |
Countries
India
Contacts
Public ContactKallol Deb
Institute of Neurosciences Kolkata
Outcome results
None listed