A Comparative study of vital parameters of two different IV anaesthetic agents and combination of both during intubation

A Comparative study of hemodynamic response of propofol, etomidate and admixture of etomidate-propofol during endotracheal intubation - A prospective randomized control study - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/02/062662

Enrollment

105

Registered

2024-02-15

Start date

Unknown

Completion date

Unknown

Last updated

2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: Z049- Encounter for examination and observation for unspecified reason Health Condition 2: R69- Illness, unspecified Health Condition 3: R69- Illness, unspecified Health Condition 4: R69- Illness, unspecified

Interventions

Intervention1: propofol: inj propofol 2-3mg/kg i.v is the induction agent used for comaparing with etomidate and their hemodynamic responses are evaluated Intervention2: etomidate: inj etomidate 0.3

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients willing to consent for the study 2.Elective surgery under general anaesthesia with endotracheal intubation 3.ASA class 1, 2, 3 4.Either gender

Exclusion criteria

Exclusion criteria: 1.Difficult airway 2.Pregnancy 3.severe cardiopulmonary or liver disease , hypotension , shock 4.Presence of known primary or secondary adrenal insufficiency 5.Patient on steroid medication 6.Allergic to propofol and etomidate 7.Patients BMI equal or greater than 40kg/m2

Design outcomes

Primary

Measure	Time frame
To compare the hemodynamic parameters (HR, SBP,DBP,MBP)Timepoint: From start of induction till 1hour & thereafter 10 minutes postop	—

Secondary

Measure	Time frame
To compare the adverse effects at the time of induction such as myoclonus , pain on injection . To compare perioperative complications such as intraoperative arrhythmias , desaturation , postoperative nausea & vomiting and thrombophlebitisTimepoint: from induction till 24 hours of postoperative period	—

Countries

India

Contacts

Public ContactDr smita R Engineer

BJMC civil hospital asarwa ahmedabad

seng_90@yahoo.com9825504948

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026