Health Condition 1: N189- Chronic kidney disease, unspecified
Conditions
Interventions
Intervention1: Desidustat: Tab desidustat 50 mg orally three times a week with maximum dose increased Upto 150 mg three times a week depend on hemoglobin level.
Control Intervention1: Erythropoietin:
Sponsors
Dr Sachin Sharma
MultiDisciplinary Research Unit
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patient willing to give written informed consent. 2.Age more than 18 years. 3.Male or female patient with current clinical diagnosis of anemia due to CKD having baseline hemoglobin concentrations
Exclusion criteria
Exclusion criteria: 1.Age less than 18 years. 2.Patients who received red blood cell transfusion within 8 weeks prior to enrollment. 3.Hematological malignancy or primary hematological disease. 4.Malignancy of any organ. 5.Presence or a history of bleeding disorder. 6.Serological status reflecting active hepatitis B or C or Human immunodeficiency virus (HIV) infection. 7.History of renal transplant. 8.Unable to swallow tablets or disease significantly affecting gastrointestinal function and/or inhibiting small intestinal absorption such as mal absorption syndrome, resection of small bowel or poorly controlled inflammatory bowel disease affecting small intestine. 9.History of uncontrolled autoimmune hemolytic anemia, idiopathic thrombocytopenic purpura (ITP) or thalassemia. 10.Known hypersensitivity to investigational products or with known contraindications to any of the study drug. 11.Women who are trying to conceive, pregnant and breast-feeding women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean change in hemoglobin.Timepoint: Baseline to 3 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in hematological and biochemical parameters as mentioned in protocol annexure III) before and after receiving drug like Serum Hepcidin level, Vitamin D, Phosphate, Parathormone, Lipid Profile Timepoint: Baseline to 3 months | — |
Countries
India
Contacts
Public ContactDr Abhinav Rana
Dr Rajendra Prasad Government Medical College Tanda HP
Outcome results
None listed