Testing the efficacy of remineralising toothpaste containing calcium sucrose phospate, casein phospopeptide amorphous calcium phosphate fluoride and nanohydroxyapatite in the prevention of white spot lesions in people with metal braces

Comparison Among Three Remineralising Agents; Calcium Sucrose Phosphate, Casein Phosphopeptide–Amorphous Calcium Phosphate Fluoride and Nanohydroxyapatite in Prevention of the White Spot Lesions During Fixed Orthodontic Treatment: A Double-Blind Randomized Control Trial - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/02/062619

Enrollment

Registered

2024-02-14

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K038- Other specified diseases of hard tissues of teeth

Interventions

Intervention1: Toothmin toothpaste: calcium sucrose phosphate Intervention2: GC Tooth Mousse: Casein phosphopeptide -amorphous calcium phosphate fluoride Intervention3: Dente 91: Nanohydroxyapatite Co

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patient with age between 15-25 years undergoing fixed orthodontic treatment with metal brackets. 2. Patients with satisfactory general health. 3. Patients with good and fair oral hygiene 4. Patients with mild dental crowding 5. Patients participating in the study voluntarily

Exclusion criteria

Exclusion criteria: 1) Enamel hypoplasia 2) Amelogenesis imperfecta 3) Fluorosis 4) Active periodontal disease 5) Active dental caries 6) Patients having frontal fillings, veneers, or other reconstructions 7) Patients having other structural defects of enamel.

Design outcomes

Primary

Measure	Time frame
To compare the effectiveness of three remineralizing agents; calcium sucrose phosphate, casein phosphopeptide-amorphous calcium phosphate fluoride (CPP-ACP) and nanohydroxyapatite in prevention of white spot lesions in patients undergoing fixed orthodontic treatment.Timepoint: 6 months	—

Secondary

Measure	Time frame
To evaluate the first appearance of white spot lesions with the use of calcium sucrose phosphate, casein phosphopeptide-amorphous calcium phosphate fluoride and nanohydroxyapatite.Timepoint: 6 months	—

Countries

India

Contacts

Public ContactTRUPTI NAKHATE

Maharashtra Institute of Dental Sciences and Research (Dental College), Maharashtra

nakhate.trupti30@gmail.com7972151998

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026