A clinical trial to study the effect of Ketamine spray versus Dexmedetomidine spray at surgical site during closure in lumbar spine fixation surgery for postoperative pain relief

To compare the effect of Ketamine spray versus Dexmedetomidine spray at surgical site during closure in lumbar spine fixation surgery for postoperative pain relief - Prospective, Randomized, double blinded, placebo controlled study - Nil

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/02/062613

Enrollment

Registered

2024-02-14

Start date

Unknown

Completion date

Unknown

Last updated

2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Ketamine spray: Will receive Ketamine 1 mg/kg diluted in normal saline to make 20 ml solution and is sprayed over the surgical site towards the end of the surgery Control Intervention1:

Eligibility

Inclusion criteria

Inclusion criteria: Lumbar spine patients posted for spine instrumentation surgery. 2. Age group between 18 and 60 years.

Exclusion criteria

Exclusion criteria: 1. Refused to participate in the study. 2. A body mass index exceeding 30 kg/m2 3. Allergy to any studied medication 4. Hepatic or Renal insufficiency 5. Multiple level spine surgery or simultaneous/recent surgery 6. Antihypertensive medication with clonidine or other a2 agonists.

Design outcomes

Primary

Measure	Time frame
Duration of postoperative analgesia (VAS)Timepoint: 30mins,hours: 1,2,4,6,24	—

Secondary

Measure	Time frame
Total rescue analgesic requirement in 24hr. Any associated side effects like nausea /vomiting/sedation/shivering etc.Timepoint: 24 hours	—

Countries

India

Contacts

Public ContactDr Birju Manjhi

Institute of medical sciences

dryashacin1999@gmail.com9918424416

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026