To assess the effectiveness of topical EMLA cream in reducing pain during intravenous cannulation by applying over skin in children between age groups 3 years to 12 years and measuring pain using various pain scales

Efficacy of eutectic mixture of local anaesthetic cream to reduce intravenous cannulation pain in children - A randomized control study - Nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/02/062606

Enrollment

270

Registered

2024-02-14

Start date

Unknown

Completion date

Unknown

Last updated

2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R69- Illness, unspecified

Interventions

Intervention1: Eutectic mixture of local anaesthetic cream (2.5% lignocaine and 2.5% prilocaine): To assess the efficacy of Eutectic mixture of local anaesthetic cream to reduce intravenous cannulatio

Eligibility

Inclusion criteria

Inclusion criteria: 1.Children between age groups 3 years to 12 years requiring non-emergent Intravenous cannulation 2.Parents who are willing to participate in the study and giving informed written consent

Exclusion criteria

Exclusion criteria: 1.Emergency situations requiring immediate intravenous access 2.History of atopy 3.Open wounds or rash on dorsum of hand 4.Hypersensitivity to Eutectic mixture of local anaesthetic cream 5.Facial anomalies( preventing typical facial expressions of pain ) 6.Cognitive dysfunction and conditions affecting ability to rate pain 7.Local erythema or blanching following eutectic mixture of local anaesthetic cream application 8.Requiring more than one attempt for cannulation 9.Children with poorly visible veins 10.Parents not willing to participate and give consent for study

Design outcomes

Primary

Measure	Time frame
Reduction in intravenous cannulation pain using eutectic mixture of local anaesthetic cream using visual analog scale pain score and FLACC scale and 4 point pain scaleTimepoint: Outcome (reduction in intravenous cannulation pain assessed using pain scales) will be assessed at specific time based on group which participants randomized. For Group A - assessed after 30 minutes application of placebo Group B - assessed after 30 minutes application of EMLA Group C - assessed after 60 minutes application of EMLA	—

Measure

Time frame

Reduction in intravenous cannulation pain using eutectic mixture of local anaesthetic cream using visual analog scale pain score and FLACC scale and 4 point pain scaleTimepoint: Outcome (reduction in intravenous cannulation pain assessed using pain scales) will be assessed at specific time based on group which participants randomized. For Group A - assessed after 30 minutes application of placebo Group B - assessed after 30 minutes application of EMLA Group C - assessed after 60 minutes application of EMLA

—

Secondary

Measure	Time frame
To study the timing of application of topical EMLA cream for intravenous cannulation in childrenTimepoint: 30 minutes and 60 minutes application time	—

Countries

India

Contacts

Public ContactTHAMIZSELVAN G

Sri manakula vinayagar medical College and hospital

drkani88@gmail.com9952262500

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026