Effect of Probiotic on thyroid hormone

Efficacy of Probiotic on normalizationof thyroid hormone profile and gut modulation among subjects with autoimmune hypothyroidism - Randomized double blind placebo controlled trial in cross over design. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/02/062603

Enrollment

Registered

2024-02-13

Start date

Unknown

Completion date

Unknown

Last updated

2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E038- Other specified hypothyroidism

Interventions

Intervention1: Probiotics: The probiotic preparation contains a mix of 8 strains of bacteria Control Intervention1: Placebo: The placebo shall contain a specific grade of Maltose

Eligibility

Inclusion criteria

Inclusion criteria: Case of Hypothyroidism on stable Thyroxine supplementation for last 6 months. Native population (Residing in the study area for at least 5 years) Antimicrosomal antibody positive

Exclusion criteria

Exclusion criteria: Pregnancy Lactation Cigarette smoking, Alcohol addiction Thyroid tumors, infections, trauma, or history of thyroid irradiation Diseases of Pituitary or Hypothalamus causing hypothyroidism. Hypertension, Diabetes mellitus, Lipid dysregulation or any other co-morbidities PCOS, Obesity, severe anemia Recent ( sensitizers or herbal medicine Known history of disease with autoimmune diseases History of malignancy or any gastrointestinal tract surgery (e.g., gastrectomy, bariatric surgery, colectomy, ileectomy, cholecystectomy or appendectomy).

Design outcomes

Primary

Measure	Time frame
The evidence generated from the study will help to control the deregulation of thyroid hormone by treating the root cause of hypothyroidism. The results generated from the study may totally change the treatment strategy for subjects with autoimmune hypothyroidism. By normalization of thyroid hormone profile by gut modulation using probiotic, we may be able to reduce or stop the usage of thyroxin supplementation in subjects with autoimmune hypothyroidismTimepoint: 2 years	—

Measure

Time frame

The evidence generated from the study will help to control the deregulation of thyroid hormone by treating the root cause of hypothyroidism. The results generated from the study may totally change the treatment strategy for subjects with autoimmune hypothyroidism. By normalization of thyroid hormone profile by gut modulation using probiotic, we may be able to reduce or stop the usage of thyroxin supplementation in subjects with autoimmune hypothyroidismTimepoint: 2 years

—

Secondary

Measure	Time frame
By normalization of thyroid hormone profile by gut modulation using probiotic, we may be able to reduce or stop the usage of thyroxin supplementation in subjects with autoimmune hypothyroidismTimepoint: 2 years	—

Countries

India

Contacts

Public ContactDr Ram S Kaulgud

Karnataka Institute of Medical Sciences

mrukimshubli@gmail.com8073626873

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026