To study the outcome of patients treated with a combination of two or three antimicrobial drugs for the treatment of pneumonia (developed during mechanical ventilator stay) caused by microbe Acinetobacter Baumannii resistant to the commonly used broad spectrum antimicrobial (carbepenem).

Efficacy of Triple vs Double drug regimens with at least two sensitive antibiotics on the outcome of patients infected with ventilator-associated pneumonia due to carbepenam-resistant Acinetobacter Baumannii: A randomised controlled study. - NIL

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/02/062539

Enrollment

174

Registered

2024-02-12

Start date

Unknown

Completion date

Unknown

Last updated

2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: A488- Other specified bacterial diseases

Interventions

Intervention1: Triple Drug Regimen: Patients will receive minocycline 200mg bd with polymyxin and high dose sulbactam irrespective of minocycline sensitivity. Control Intervention1: Dual Drug Regimen:

Eligibility

Inclusion criteria

Inclusion criteria: Having ventilator-associated pneumonia (VAP) infection due to Carbepenam resistant A. Baumannii (CRAB) during ICU stay.

Exclusion criteria

Exclusion criteria: 1. Consent not obtained 2. Pregnant patients 3. Not treated for the infection 4. Infection not likely 5. Allergy to any drug used in the regimen

Design outcomes

Primary

Measure	Time frame
Comparison of 28-day all-cause mortality between triple and dual antibiotic drug regimen for VAP infection due to CRAB.Timepoint: Comparison of 28-day all-cause mortality between triple and dual antibiotic drug regimen for VAP infection due to CRAB.	—

Secondary

Measure	Time frame
Microbiological clearance, length of ventilator stay, length of ICU stay, antibiotic treatment duration, in-hospital mortality, secondary infections post-CRAB infection.Timepoint: During Hospital stay.	—

Countries

India

Contacts

Public ContactSadik Mohammed

AIIMS, JODHPUR

drmsadik@gmail.com9414849733

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026