Can polyethylene glycol solution be used as an alternative to lactulose in patients of hepatic encephalopathy ?

Comparative Effectiveness Of Polyethylene Glycol Electrolyte Solution Versus Lactulose For Treatment Of Hepatic Encephalopathy : A Single Blind, Randomised Control Clinical Trial - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/02/062513

Enrollment

100

Registered

2024-02-12

Start date

Unknown

Completion date

Unknown

Last updated

2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F99- Mental disorder, not otherwise specified

Interventions

Intervention1: Lactulose For Treatment Of Hepatic Encephalopathy: 90 ml of Lactulose dissolved in 750 ml of water administered orally by mouth or nasogastric tube (three doses within 24 hrs) continued

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients with any grade of hepatic encephalopathy (grade1-grade4) 2.Patients with chronic liver disease and acute on chronic liver failure of any cause.

Exclusion criteria

Exclusion criteria: patients with acute liver failure, suspected intestinal obstruction, pregnancy and lactation, uncontrolled infection and hemodynamically unstable and received more than 1 dose of lactulose prior to enrollment

Design outcomes

Primary

Measure	Time frame
1 or more scale improvement in HE grades at 24 hours, 48 hours, 72 hours and at time of discharge using Hepatic Encephalopathy Scoring Algorithm (HESA) ranging from 0 to 4Timepoint: 12 months	—

Secondary

Measure	Time frame
overall length of stay (LOS), serum ammonia concentration and time to HE resolution.Timepoint: 12 months	—

Countries

India

Contacts

Public ContactDr Anusuya Gehlot

Dr. S.N. Medical College, Jodhpur

jainsaurabh0890@gmail.com9509470890

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026