To compare the effect of putting lignocaine inside the cuff and applying water soluble gel on the outer surface of cuff of tube in windpipe with putting lignocaine alone inside the cuff on sore throat after operation

COMPARISON OF THE EFFICACY OF INTRACUFF 2% ALKALINIZED LIGNOCAINE AND WATER-SOLUBLE GEL LUBRICATION WITH INTRACUFF SALINE AND INTRACUFF 2% ALKALINIZED LIGNOCAINE IN PREVENTING POSTOPERATIVE SORE THROAT

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/02/062490

Enrollment

Registered

2024-02-09

Start date

Unknown

Completion date

Unknown

Last updated

2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: AL (Group with 2% Alkalinised lignocaine intracuff in orotracheal tube): In this group, we will putintracuff 2% alkalinized lignocaine (2% lidocaine mixed with 7.5% sodium bicarbonate,

Eligibility

Inclusion criteria

Inclusion criteria: Patients of age 18 to 65 years, of American Society of Anaesthesiologist physical status I or II, expected to undergo elective surgery of more than 2 hours duration, under general anaesthesia requiring orotracheal intubation.

Exclusion criteria

Exclusion criteria: 1. Patients with history of cough, sore throat or respiratory disease, smokers, difficult airway, modified Mallampati class 3 or 4. 2. Patients undergoing head, neck and upper airway surgeries, expected to have a difficult extubation or postoperative elective ventilation. 3. Patients allergic to study drug or receiving lignocaine in any other form.

Design outcomes

Primary

Measure	Time frame
To compare the effect of intracuff 2% alkalinized lignocaine and water-soluble gel lubrication with intracuff saline and intracuff 2% alkalinized lignocaine on the incidence of postoperative sore throat at 1 hour following extubation.Timepoint: At 1 hour post extubation	—

Secondary

Measure	Time frame
To compare the incidence of emergence cough and agitation. To compare the haemodynamic response to extubation. To compare the incidence of sore throat at 24 h.Timepoint: At 24 hour post extubation	—

Countries

India

Contacts

Public ContactDr Parul Mullick

VMMC and Safdarjung Hospital

drparulmullick@gmail.com919810606262

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026